Cochrane · systematic review · CD002745
Amantadine and rimantadine for influenza A in children and the elderly
Alves Galvão, MG, Rocha Crispino Santos, MA, Alves da Cunha, AJL · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
26
current version
GRADE rated
14
No studies
3
Included studies
NR
No studies 3 · 11.5%Ungraded 9 · 34.6%Very low 5 · 19.2%Low 7 · 26.9%Moderate 2 · 7.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyComparison
Population: children with no influenza A infection (prevention) or with influenza A infection (treatment)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of influenza A during prophylaxis ( | RR 0.11 [0.04, 0.3] | 2 studies · 773 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Fever after initiation of treatment ( | RR 0.37 [0.08, 1.75] | 2 studies · 104 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Cough after initiation of treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Dizziness ( | RR 6.63 [0.32, 137.33] | 2 studies · 599 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Nausea/vomiting ( | RR 0.54 [0.15, 2] | 2 studies · 599 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Stimulation/insomnia ( | RR 0.46 [0.12, 1.74] | 2 studies · 599 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Comparison
Population: children with no influenza A infection (prevention) or with influenza A infection (treatment)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of influenza A during prophylaxis ( | RR 0.49 [0.21, 1.15] | 3 studies · 178 participants | Low Downgraded: risk of bias, imprecision |
Fever after initiation of treatment ( | RR 0.36 [0.14, 0.91] | 1 study · 69 participants | Moderate Downgraded: risk of bias, imprecision |
Cough after initiation of treatment ( | RR 0.83 [0.63, 1.1] | 1 study · 69 participants | Moderate Downgraded: risk of bias, imprecision |
Dizziness ( | RR 3.21 [0.14, 75.68] | 1 study · 56 participants | Very low Downgraded: risk of bias, imprecision |
Nausea/vomiting ( | RR 0.96 [0.1, 9.01] | 2 studies · 125 participants | Low Downgraded: risk of bias, imprecision |
Stimulation/insomnia | no estimate extracted | 0 studies · 0 participants | Ungraded |
Comparison
Population: elderly people with no influenza A infection (prevention) or with influenza A infection (treatment)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of influenza A during prophylaxis | no estimate extracted | 0 studies · 0 participants | Ungraded |
Fever after initiation of treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Cough after initiation of treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Dizziness | no estimate extracted | 0 studies · 0 participants | Ungraded |
Nausea | no estimate extracted | 0 studies · 0 participants | Ungraded |
Vomiting | no estimate extracted | 0 studies · 0 participants | Ungraded |
Stimulation/insomnia | no estimate extracted | 0 studies · 0 participants | Ungraded |
Comparison
Population: elderly people with no influenza A infection (prevention) or with influenza A infection (treatment)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of influenza A during prophylaxis | RR 0.45 [0.14, 1.41] | 2 studies · 103 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Fever after initiation of treatment | no estimate extracted | NR | No studies |
Cough after initiation of treatment | no estimate extracted | NR | No studies |
Dizziness ( | no estimate extracted | NR | No studies |
Nausea ( | RR 1.99 [0.45, 8.75] | 2 studies · 233 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vomiting ( | RR 0.99 [0.38, 2.6] | 2 studies · 233 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Stimulation/insomnia ( | RR 1.61 [0.43, 6.02] | 2 studies · 233 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Comparison
Population: children with no influenza A infection (prevention) or with influenza a (treatment)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of influenza A during prophylaxis ( | RR 0.11 [0.04, 0.3] | 773 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Fever after initiation of treatment ( | RR 0.37 [0.08, 1.75] | 2 studies · 104 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Cough after initiation of treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Dizziness ( | RR 6.63 [0.32, 137.33] | 2 studies · 599 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Nausea/ vomiting ( | RR 0.54 [0.15, 2] | 2 studies · 599 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Stimulation/ insomnia ( | RR 0.46 [0.12, 1.74] | 2 studies · 599 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Comparison
Population: children with no influenza A infection (prevention) or with influenza a (treatment)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of influenza A during prophylaxis ( | RR 0.49 [0.21, 1.15] | 3 studies · 178 participants | Low Downgraded: risk of bias, imprecision |
Fever after initiation of treatment ( | RR 0.36 [0.14, 0.91] | 1 study · 69 participants | Moderate Downgraded: risk of bias, imprecision |
Cough after initiation of treatment ( | RR 0.83 [0.63, 1.1] | 1 study · 69 participants | Moderate Downgraded: risk of bias, imprecision |
Dizziness ( | RR 3.21 [0.14, 75.68] | 1 study · 56 participants | Very low Downgraded: risk of bias, imprecision |
Nausea/vomiting ( | RR 0.96 [0.1, 9.01] | 2 studies · 125 participants | Low Downgraded: risk of bias, imprecision |
Stimulation/insomnia | no estimate extracted | 0 studies · 0 participants | Ungraded |
Comparison
Population: elderly people with no influenza A infection (prevention) or with influenza a (treatment)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of influenza A during prophylaxis | no estimate extracted | 0 studies · 0 participants | Ungraded |
Fever after initiation of treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Cough after initiation of treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Dizziness | no estimate extracted | 0 studies · 0 participants | Ungraded |
Nausea | no estimate extracted | 0 studies · 0 participants | Ungraded |
Vomiting | no estimate extracted | 0 studies · 0 participants | Ungraded |
Stimulation/insomnia | no estimate extracted | 0 studies · 0 participants | Ungraded |
Comparison
Population: elderly people with no influenza A infection (prevention) or with influenza a (treatment)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of influenza A during prophylaxis | RR 0.45 [0.14, 1.41] | 2 studies · 103 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Fever after initiation of treatment | no estimate extracted | NR | No studies |
Cough after initiation of treatment | no estimate extracted | NR | No studies |
Dizziness ( | no estimate extracted | NR | No studies |
Nausea ( | RR 1.99 [0.45, 8.75] | 2 studies · 233 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vomiting ( | RR 0.99 [0.38, 2.6] | 2 studies · 233 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Stimulation/insomnia ( | RR 1.61 [0.43, 6.02] | 2 studies · 233 participants | Low Downgraded: risk of bias, imprecision, inconsistency |