Cochrane · systematic review · CD002200
Follow‐up strategies for patients treated for non‐metastatic colorectal cancer
Jeffery, M, Hickey, BE, Hider, PN · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 0 · 0%Moderate 2 · 33.3%High 3 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyIntensive follow‐up compared to less intensive follow‐up for patients treated for colorectal cancer with curative intent
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Intensive follow‐up vs less intensive follow‐up | HR 0.91 [0.8, 1.04] | 15 studies · 12528 participants | High |
Colorectal cancer‐specific survival Intensive follow‐up vs less intensive follow‐up | HR 0.93 [0.81, 1.07] | 11 studies · 11771 participants | Moderate Downgraded: risk of bias, imprecision |
Relapse‐free survival Intensive follow‐up vs less intensive follow‐up | HR 1.05 [0.92, 1.21] | 16 studies · 8047 participants | High |
Salvage surgery (surgery at relapse with curative intent) Intensive follow‐up vs less intensive follow‐up | RR 1.98 [1.53, 2.56] | 13 studies · 5157 participants | High |
Interval recurrences (recurrence CRC diagnosed between scheduled Intensive follow‐up vs less intensive follow‐up | RR 0.59 [0.41, 0.86] | 7 studies · 3933 participants | Moderate Downgraded: risk of bias, inconsistency |
Harms Colonoscopy complications ‐ bowel perforation Intensive follow‐up vs less intensive follow‐up | RR 6.83 [0.36, 131.21] | 1 study · 326 participants | Very low Downgraded: risk of bias, imprecision |
Follow‐up strategies for patients treated for non‐metastatic colorectal cancer
Population: colorectal cancer treated with curative intent
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival (OS) | HR 0.92 [0.77, 1.09] | 12 studies · 4786 participants | High |
Colorectal cancer‐specific survival (CC‐SS) | HR 0.93 [0.78, 1.12] | 7 studies · 3822 participants | Moderate Downgraded: risk of bias, inconsistency |
Relapse‐free survival (R‐FS) | HR 1.03 [0.9, 1.18] | 14 studies · 5253 participants | Moderate Downgraded: risk of bias, inconsistency |
Salvage surgery (SS) | RR 1.98 [1.53, 2.56] | 13 studies · 5157 participants | High |
Interval recurrences (IR) | RR 0.59 [0.41, 0.86] | 6 studies · 3933 participants | Moderate Downgraded: risk of bias, inconsistency |
Adverse effects | RR 2.08 [0.11, 40.42] | 1 study · 1381 participants | Moderate Downgraded: risk of bias, inconsistency |