Cochrane · systematic review · CD002190

Vaccines for the common cold

Montesinos-Guevara, C, Buitrago-Garcia, D, Felix, ML, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library

Acute Respiratory Infections3 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 1 · 33.3%Ungraded 0 · 0%Very low 2 · 66.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Virus vaccines compared to placebo for preventing the common cold in healthy people

Population: young, healthy men in a military facility

CD002190.PUB6 (current) · 3 questions

Outcome	Effect	Evidence	Status / GRADE
Incidence of the common cold Number of participants with common cold by group Virus vaccines vs placebo	RR 0.95 [0.45, 2.02]	1 study · 2307 participants	Very low Downgraded: risk of bias, imprecision, indirectness
Vaccine safety Virus vaccines vs placebo	no estimate extracted	1 study · 2307 participants	Very low Downgraded: risk of bias, imprecision, indirectness
Mortality: vaccine related and all cause ‐ not reported Virus vaccines vs placebo	no estimate extracted	NR	No studies

Virus vaccines compared to placebo for preventing the common cold in healthy people

Population: healthy people

CD002190.PUB5 · 3 questions

Outcome	Effect	Evidence	Status / GRADE
Incidence of the common cold Number of participants with common cold by group Virus vaccines vs placebo	RR 0.95 [0.45, 2.02]	1 study · 2307 participants	Low Downgraded: risk of bias, imprecision
Vaccine safety Virus vaccines vs placebo	no estimate extracted	1 study · 2307 participants	Low Downgraded: risk of bias, imprecision
Mortality related to the vaccine ‐ not reported Virus vaccines vs placebo	no estimate extracted	NR	No studies

Virus vaccines compared to placebo for preventing the common cold in healthy people

Population: healthy people

CD002190.PUB4 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Incidence of the common cold Number of participants with common cold by group Virus vaccines vs placebo	RR 0.95 [0.45, 2.02]	1 study · 2307 participants	Low Downgraded: risk of bias, imprecision