Cochrane · systematic review · CD002009
Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis
Bhatt, J, Jahnke, N, Smyth, AR · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyComparison
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lung function Mean percentage change in FEV1 | no estimate extracted | 3 studies · 289 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Lung function Mean percentage change in FVC (% predicted) | no estimate extracted | 2 studies · 70 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Nutritional status BMI | no estimate extracted | 1 study · 41 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Time to first exacerbation requiring intravenous antibiotics | no estimate extracted | 1 study · 113 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Antibiotic resistance patterns following treatment | no estimate extracted | NR | No studies |
Ototoxicity An increase in auditory threshold of 20 dB or more over any frequency range | RR 0.56 [0.04, 7.96] | 3 studies · 266 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Nephrotoxicity The percentage change in creatinine over baseline | no estimate extracted | 3 studies · 245 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Comparison
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lung function Mean percentage change in FEV₁ | no estimate extracted | 3 studies · 289 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Lung function Mean percentage change in FVC (% predicted) | no estimate extracted | 2 studies · 70 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Nutritional status BMI | no estimate extracted | 1 study · 41 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Time to first exacerbation requiring intravenous antibiotics | no estimate extracted | 1 study · 113 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Antibiotic resistance patterns following treatment | no estimate extracted | NR | No studies |
Ototoxicity An increase in auditory threshold of 20 dB or more over any frequency range | RR 0.56 [0.04, 7.96] | 3 studies · 266 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Nephrotoxicity The percentage change in creatinine over baseline | no estimate extracted | 3 studies · 245 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |