Cochrane · systematic review · CD001912
Prophylactic anti‐staphylococcal antibiotics for cystic fibrosis
Rosenfeld, M, Rayner, O, Smyth, AR · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySummary of findings ‐ Prophylactic compared with 'as required' anti‐staphylococcal antibiotics for cystic fibrosis
Population: children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1 (% predicted (Knudson 1983)) Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | no estimate extracted | 1 study · 119 participants | Low Downgraded: risk of bias, imprecision |
Number of people with one or more isolates of S aureus (sensitive strains) Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | OR 0.21 [0.13, 0.35] | 3 studies · 315 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of people with one or more isolates of P aeruginosa Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | OR 0.74 [0.45, 1.23] | 3 studies · 312 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of people needing additional antibiotics Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | OR 0.18 [0.01, 3.6] | 1 study · 119 participants | Low Downgraded: risk of bias |
Weight (z score) Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | no estimate extracted | 2 studies · 140 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Acquisition of multiply‐resistant S aureus Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | no estimate extracted | NR | No studies |
Adverse events of treatment Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | no estimate extracted | 1 study · 119 participants | Low Downgraded: risk of bias, imprecision |
Summary of findings ‐ Prophylactic compared with 'as required' anti‐staphylococcal antibiotics for cystic fibrosis
Population: children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV₁ (% predicted (Knudson 1983)) Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | no estimate extracted | 1 study · 119 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of people with one or more isolates of S aureus (sensitive strains) Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | OR 0.21 [0.13, 0.35] | 3 studies · 315 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of people with one or more isolates of P aeruginosa Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | OR 0.74 [0.45, 1.23] | 3 studies · 312 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of people needing additional antibiotics Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | OR 0.18 [0.01, 3.6] | 1 study · 119 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Weight (z score) Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | no estimate extracted | 2 studies · 140 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Acquisition of multiply‐resistant S aureus Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | no estimate extracted | NR | No studies |
Adverse events of treatment Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics | no estimate extracted | 1 study · 119 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |