Cochrane · systematic review · CD001892
Low protein diets for non‐diabetic adults with chronic kidney disease
Hahn, D, Hodson, EM, Fouque, D · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 33.3%Low 3 · 33.3%Moderate 3 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyLow protein diet versus normal protein diet for non‐diabetic adults with chronic kidney disease (CKD)
Population: non‐diabetic adults with CKD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (all causes) Low protein diet vs normal protein diet | RR 0.77 [0.51, 1.18] | 5 studies · 1680 participants | Moderate |
ESKD Low protein diet vs normal protein diet | RR 1.05 [0.73, 1.53] | 6 studies · 1814 participants | Low |
End or change in GFR Low protein diet vs normal protein diet | no estimate extracted | 8 studies · 1680 participants | Very low |
Very low protein diet versus low or normal protein diet for non‐diabetic adults with chronic kidney disease (CKD)
Population: non‐diabetic adults with CKD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (all causes) Very low protein diet vs low or normal protein diet | RR 1.26 [0.62, 2.54] | 6 studies · 681 participants | Moderate |
ESKD Very low protein diet vs low or normal protein diet | RR 0.64 [0.49, 0.85] | 10 studies · 1010 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
End or change in GFR Very low protein diet vs low or normal protein diet | no estimate extracted | 6 studies · 456 participants | Low |
Nutritional measures for non‐diabetic adults with chronic kidney disease (CKD)
Population: non‐diabetic adults with CKD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Final body weight: low protein versus normal protein diet | no estimate extracted | 2 studies · 223 participants | Very low Downgraded: risk of bias |
Final body weight: very low protein diet versus low protein diet | no estimate extracted | 4 studies · 291 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Protein energy wasting (malnutrition) | RR 1.31 [0.42, 4.13] | 15 studies · 2373 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Low protein diet versus normal protein diet for non‐diabetic adults with chronic kidney disease (CKD)
Population: non‐diabetic adults with CKD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (all causes) Low protein diet vs normal protein diet | RR 0.77 [0.51, 1.18] | 5 studies · 1680 participants | Moderate |
ESKD Low protein diet vs normal protein diet | RR 1.05 [0.73, 1.53] | 6 studies · 1814 participants | Low |
End or change in GFR Low protein diet vs normal protein diet | no estimate extracted | 8 studies · 1680 participants | Very low |
Very low protein diet versus low or normal protein diet for non‐diabetic adults with chronic kidney disease (CKD)
Population: non‐diabetic adults with CKD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (all causes) Very low protein diet vs low or normal protein diet | RR 1.26 [0.62, 2.54] | 6 studies · 681 participants | Moderate |
ESKD Very low protein diet vs low or normal protein diet | RR 0.64 [0.49, 0.85] | 10 studies · 1010 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
End or change in GFR Very low protein diet vs low or normal protein diet | no estimate extracted | 6 studies · 456 participants | Low |
Nutritional measures for non‐diabetic adults with chronic kidney disease (CKD)
Population: non‐diabetic adults with CKD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Final body weight: low protein versus normal protein diet | no estimate extracted | 2 studies · 223 participants | Very low Downgraded: risk of bias |
Final body weight: very low protein diet versus low protein diet | no estimate extracted | 4 studies · 291 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Protein energy wasting (malnutrition) | RR 1.31 [0.42, 4.13] | 15 studies · 2373 participants | Low Downgraded: risk of bias, imprecision, inconsistency |