Cochrane · systematic review · CD001860
Antibiotics for trachoma
Evans, JR, Solomon, AW, Kumar, R, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
8
No studies
5
Included studies
NR
No studies 5 · 31.3%Ungraded 3 · 18.8%Very low 1 · 6.3%Low 7 · 43.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAntibiotic versus control for trachoma: individuals
Population: people (any age) with active trachoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Active trachoma Clinical assessment: active trachoma defined as TF, TI, or both  Antibiotic vs control | RR 0.78 [0.69, 0.89] | 9 studies · 1961 participants | Low Downgraded: risk of bias, inconsistency |
Ocular C trachomatis infection Positive test for C trachomatis infection identified by culture, staining on conjunctival smears, or nucleic acid amplification methods Antibiotic vs control | RR 0.81 [0.63, 1.04] | 4 studies · 297 participants | Low Downgraded: risk of bias, imprecision |
Antibiotic resistance Proportion of samples showing evidence of resistance to antibiotic Antibiotic vs control | no estimate extracted | NR | No studies |
Adverse effects Antibiotic vs control | no estimate extracted | 9 studies · 1961 participants | Low Downgraded: risk of bias, imprecision |
Oral versus topical antibiotic for trachoma: individuals
Population: people (any age) with active trachoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Active trachoma Clinical assessment: active trachoma defined as TF, TI, or both Oral vs topical antibiotic | RR 0.97 [0.81, 1.16] | 6 studies · 953 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Ocular C trachomatis infection Positive test for C trachomatis infection identified by culture, staining on conjunctival smears, or nucleic acid amplification methods Oral vs topical antibiotic | no estimate extracted | 3 studies · 298 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Antibiotic resistance Proportion of samples showing evidence of resistance to antibiotic Oral vs topical antibiotic | no estimate extracted | NR | No studies |
Adverse effects Oral vs topical antibiotic | no estimate extracted | 8 studies · 1583 participants | Low Downgraded: risk of bias, imprecision |
Oral azithromycin compared to control for trachoma: communities
Population: people (any age) with active trachoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Active trachoma Clinical assessment: active trachoma defined as TF, TI, or both Oral azithromycin vs control | no estimate extracted | NR | No studies |
Ocular C trachomatis infection Oral azithromycin vs control | no estimate extracted | NR | No studies |
Antibiotic resistance Proportion of samples showing evidence of resistance to antibiotic Oral azithromycin vs control | no estimate extracted | 4 studies · 1354 participants | Ungraded |
Adverse effects Oral azithromycin vs control | no estimate extracted | 2 studies · 3069 participants | Ungraded |
Oral azithromycin compared to topical tetracycline for trachoma: communities
Population: people (any age) with active trachoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Active trachoma Clinical assessment: active trachoma defined as TF, TI, or both Oral azithromycin vs topical tetracycline | no estimate extracted | 3 studies · 6002 participants | Low Downgraded: risk of bias, inconsistency |
Ocular C trachomatis infection Positive test for C trachomatis infection identified by culture, staining on conjunctival smears, or nucleic acid amplification methods Oral azithromycin vs topical tetracycline | no estimate extracted | 3 studies · 5773 participants | Low Downgraded: risk of bias, inconsistency |
Antibiotic resistance Proportion of samples showing evidence of resistance to antibiotic Oral azithromycin vs topical tetracycline | no estimate extracted | NR | No studies |
Adverse effects Oral azithromycin vs topical tetracycline | no estimate extracted | 3 studies · 6002 participants | Ungraded |
Antibiotic versus control for trachoma: individuals
Population: patients with trachoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Active trachoma Antibiotic vs control | RR 0.78 [0.69, 0.89] | 9 studies · 1961 participants | Low Downgraded: risk of bias, inconsistency |
Ocular chlamydia trachomatis infection Antibiotic vs control | RR 0.81 [0.63, 1.04] | 4 studies · 297 participants | Low Downgraded: risk of bias, imprecision |
Active trachoma Antibiotic vs control | RR 0.74 [0.55, 1] | 4 studies · 1035 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Ocular chlamydial trachomatis infection Antibiotic vs control | RR 0.25 [0.08, 0.78] | 1 study · 129 participants | Low Downgraded: risk of bias |
Oral versus topical antibiotic for trachoma: individuals
Population: patients with trachoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Active trachoma Oral vs topical antibiotic | RR 0.98 [0.82, 1.18] | 6 studies · 953 participants | Moderate Downgraded: risk of bias |
Ocular chlamydia trachomatis infection Oral vs topical antibiotic | no estimate extracted | 3 studies · 298 participants | Very low Downgraded: risk of bias, inconsistency |
Active trachoma Oral vs topical antibiotic | RR 0.93 [0.75, 1.15] | 5 studies · 886 participants | Very low Downgraded: risk of bias, inconsistency |
Ocular chlamydia trachomatis infection Oral vs topical antibiotic | no estimate extracted | 2 studies · 220 participants | Very low Downgraded: risk of bias, inconsistency |
Oral azithromycin compared to control for trachoma: communities
Population: patients with trachoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Active trachoma Oral azithromycin vs control | no estimate extracted | 2 studies · 2764 participants | Moderate Downgraded: risk of bias, inconsistency |
Ocular chlamydia trachomatis infection Oral azithromycin vs control | RR 0.35 [0.21, 0.6] | 4 studies · 4345 participants | Moderate Downgraded: risk of bias, inconsistency |
Oral azithromycin compared to topical tetracycline for trachoma: communities
Population: patients with trachoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Active trachoma Oral azithromycin vs topical tetracycline | no estimate extracted | 3 studies · 6002 participants | Low Downgraded: risk of bias, inconsistency |
Ocular C. trachomatis infection Oral azithromycin vs topical tetracycline | no estimate extracted | 3 studies · 5773 participants | Low Downgraded: risk of bias, inconsistency |
Active trachoma Oral azithromycin vs topical tetracycline | no estimate extracted | 3 studies · 5414 participants | Low Downgraded: risk of bias, inconsistency |
Ocular C. trachomatis infection Oral azithromycin vs topical tetracycline | no estimate extracted | 3 studies · 5276 participants | Low Downgraded: risk of bias, inconsistency |