Cochrane · systematic review · CD001511
Glucocorticosteroids for people with alcoholic hepatitis
Pavlov, CS, Varganova, DL, Casazza, G, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 83.3%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyGlucocorticosteroids for people with alcoholic hepatitis
Population: participants with alcoholic hepatitis at high risk of mortality and morbidity
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality: up to 3 months' | RR 0.9 [0.7, 1.15] | 15 studies · 1861 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Health‐related quality of life: up to 3 months ( | no estimate extracted | 1 study · 377 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events during treatment | RR 1.05 [0.85, 1.29] | 15 studies · 1861 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Liver‐related mortality: up to 3 months' | RR 0.89 [0.69, 1.14] | 15 studies · 1861 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Participants with any complication: up to 3 months following randomisation | RR 1.04 [0.86, 1.27] | 15 studies · 1861 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Participants with non‐serious adverse events: up to 3 months' | RR 1.99 [0.72, 5.48] | 4 studies · 160 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Glucocorticosteroids for people with alcoholic hepatitis
Population: participants with alcoholic hepatitis at high risk of mortality and morbidity
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality: 3 months following randomisation | RR 0.9 [0.7, 1.15] | 15 studies · 1861 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Health‐related quality of life: up to 3 months ( | no estimate extracted | 1 study · 377 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Serious adverse events during treatment | RR 1.05 [0.85, 1.29] | 15 studies · 1861 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Liver‐related mortality: up to 3 months following randomisation | RR 0.89 [0.69, 1.14] | 15 studies · 1861 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Any complication: up to 3 months following randomisation | RR 1.04 [0.86, 1.27] | 15 studies · 1861 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Number of participants with non‐serious adverse events: up to 3 months' | RR 1.99 [0.72, 5.48] | 4 studies · 160 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |