Cochrane · systematic review · CD001031
Lamotrigine versus carbamazepine monotherapy for epilepsy: an individual participant data review
Nevitt, SJ, Tudur Smith, C, Weston, J, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 2 · 28.6%High 3 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySummary of findings: lamotrigine compared with carbamazepine for epilepsy (primary outcomes)
Population: adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure types)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to treatment failure (any reason related to treatment) All participants Range of Summary of findings: lamotrigine vs carbamazepine | HR 0.71 [0.62, 0.82] | 9 studies · 2481 participants | Moderate Downgraded: risk of bias, indirectness |
Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of Summary of findings: lamotrigine vs carbamazepine | HR 0.74 [0.64, 0.86] | 9 studies · 2182 participants | Moderate Downgraded: risk of bias, indirectness |
Time to treatment failure (any reason related to treatment) Subgroup: generalised onset seizures Range of Summary of findings: lamotrigine vs carbamazepine | HR 0.51 [0.33, 0.78] | 6 studies · 299 participants | Low Downgraded: risk of bias, indirectness |
Summary of findings: lamotrigine compared with carbamazepine for epilepsy (secondary outcomes)
Population: adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure types)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to first seizure All participants Range of Summary of findings: lamotrigine vs carbamazepine | HR 1.26 [1.12, 1.41] | 9 studies · 2476 participants | High |
Time to first seizure Subgroup: focal onset seizures Range of Summary of findings: lamotrigine vs carbamazepine | HR 1.29 [1.14, 1.45] | 9 studies · 2177 participants | High |
Time to first seizure Subgroup: generalised onset seizures Range of Summary of findings: lamotrigine vs carbamazepine | HR 0.98 [0.65, 1.48] | 6 studies · 277 participants | Low Downgraded: risk of bias, indirectness |
Time to 12‐month remission All participants Range of Summary of findings: lamotrigine vs carbamazepine | HR 0.91 [0.77, 1.07] | 2 studies · 988 participants | High |
Summary of findings ‐ Lamotrigine compared with carbamazepine for epilepsy (primary outcomes)
Population: adults and children with partial onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure types)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to withdrawal of allocated treatment (adjusted for epilepsy type) Range of Summary of findings ‐ Lamotrigine vs carbamazepine | HR 0.71 [0.62, 0.81] | 9 studies · 2481 participants | Moderate Downgraded: risk of bias, indirectness |
Time to withdrawal of allocated treatment Subgroup: partial onset seizures Range of Summary of findings ‐ Lamotrigine vs carbamazepine | HR 0.75 [0.64, 0.86] | 9 studies · 2182 participants | Moderate Downgraded: risk of bias, indirectness |
Time to withdrawal of allocated treatment Subgroup: generalised onset seizures Range of Summary of findings ‐ Lamotrigine vs carbamazepine | HR 0.46 [0.3, 0.71] | 6 studies · 299 participants | Low Downgraded: risk of bias, indirectness |
Summary of findings ‐ Lamotrigine compared with carbamazepine for epilepsy (secondary outcomes)
Population: adults and children with partial onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure types)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to first seizure (adjusted for epilepsy type) Range of Summary of findings ‐ Lamotrigine vs carbamazepine | HR 1.26 [1.12, 1.41] | 9 studies · 2476 participants | High |
Time to first seizure Subgroup: partial onset seizures Range of Summary of findings ‐ Lamotrigine vs carbamazepine | HR 1.29 [1.14, 1.45] | 9 studies · 2177 participants | High |
Time to first seizure Subgroup: generalised onset seizures Range of Summary of findings ‐ Lamotrigine vs carbamazepine | HR 0.98 [0.65, 1.48] | 6 studies · 277 participants | Low Downgraded: risk of bias, indirectness |
Time to 12‐month remission Range of Summary of findings ‐ Lamotrigine vs carbamazepine | HR 0.91 [0.77, 1.07] | 2 studies · 988 participants | High |