Cochrane · systematic review · CD000371
Public health deworming programmes for soil‐transmitted helminths in children living in endemic areas
Taylor‐Robinson, DC, Maayan, N, Donegan, S, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 12.5%Very low 4 · 25%Low 5 · 31.3%Moderate 5 · 31.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMultiple doses of deworming drugs compared to placebo for soil‐transmitted intestinal worms in children
Population: public health programmes to regularly treat all children aged 16 years or less
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight (kg) Multiple doses of deworming drugs vs placebo | no estimate extracted | 18 studies · 52448 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Height (cm) Multiple doses of deworming drugs vs placebo | no estimate extracted | 13 studies · 13700 participants | Moderate Downgraded: risk of bias |
Haemoglobin (g/dL) Multiple doses of deworming drugs vs placebo | no estimate extracted | 9 studies · 5498 participants | Moderate Downgraded: risk of bias |
Formal tests of cognition Multiple doses of deworming drugs vs placebo | no estimate extracted | 8 studies · 35394 participants | Moderate Downgraded: risk of bias |
Physical fitness ‐ not measured Multiple doses of deworming drugs vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
School attendance Multiple doses of deworming drugs vs placebo | no estimate extracted | 3 studies · 20650 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
School performance Multiple doses of deworming drugs vs placebo | no estimate extracted | 4 studies · 34967 participants | Moderate Downgraded: risk of bias |
Mortality (between ages 1 and 6 years) Multiple doses of deworming drugs vs placebo | RR 0.95 [0.89, 1.92] | 3 studies · 1005135 participants | Low Downgraded: risk of bias, indirectness |
A single dose of deworming drugs compared to placebo for soil‐transmitted intestinal worms in children
Population: public health programmes to regularly treat all children aged 16 years or less
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight (kg) A single dose of deworming drugs vs placebo | no estimate extracted | 14 studies · 4970 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Height (cm) A single dose of deworming drugs vs placebo | no estimate extracted | 10 studies · 2621 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Haemoglobin (g/dL) A single dose of deworming drugs vs placebo | no estimate extracted | 5 studies · 1252 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Formal tests of cognition A single dose of deworming drugs vs placebo | no estimate extracted | 5 studies · 1596 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Physical fitness A single dose of deworming drugs vs placebo | no estimate extracted | 3 studies · 280 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
School attendance A single dose of deworming drugs vs placebo | no estimate extracted | 1 study · 304 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
School performance A single dose of deworming drugs vs placebo | no estimate extracted | 1 study · 304 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Mortality A single dose of deworming drugs vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Multiple doses of deworming drugs given to all children, longest follow‐up
Population: School‐aged children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight (kg) | no estimate extracted | 10 studies · 38392 participants | Low Downgraded: risk of bias, inconsistency |
Height (cm) | no estimate extracted | 7 studies · 7057 participants | Moderate Downgraded: risk of bias |
Haemoglobin (g/dL) | no estimate extracted | 7 studies · 3595 participants | Low Downgraded: risk of bias, indirectness |
Formal tests of cognition | no estimate extracted | 5 studies · 32486 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Physical well‐being | no estimate extracted | 0 studies · 0 participants | Ungraded |
School attendance | no estimate extracted | 2 studies · 20243 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
School performance | no estimate extracted | 2 studies · 32659 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Death (between ages 1 and 6 years) | RR 0.95 [0.89, 1.92] | 3 studies · 1005135 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Single dose of deworming drugs given to infected children
Population: Children known to be infected with soil‐transmitted intestinal worms
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight (kg) | no estimate extracted | 5 studies · 627 participants | Low Downgraded: risk of bias, inconsistency |
Haemoglobin (g/dL) | no estimate extracted | 2 studies · 247 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Formal tests of cognition | no estimate extracted | 2 studies · 103 participants | Very low Downgraded: risk of bias, indirectness |
Physical well‐being | no estimate extracted | 3 studies · 280 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
School attendance | no estimate extracted | 0 studies · 0 participants | Ungraded |
Single dose of deworming drugs given to all children
Population: All children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight (kg) | no estimate extracted | 7 studies · 2719 participants | Moderate Downgraded: risk of bias |
Haemoglobin (g/dL) | no estimate extracted | 3 studies · 1005 participants | Moderate Downgraded: risk of bias |
Formal tests of cognition | no estimate extracted | 2 studies · 1361 participants | Low Downgraded: risk of bias, indirectness |
Physical well‐being | no estimate extracted | 0 studies · 0 participants | Ungraded |
School attendance | no estimate extracted | 0 studies · 0 participants | Ungraded |
Multiple dose deworming drugs for treating soil‐transmitted intestinal worms in children: effects on nutrition and school performance (outcomes measured at more than 1 year)
Population: School‐aged children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight (kg) | no estimate extracted | 5 studies · 37306 participants | Low Downgraded: risk of bias |
Height (cm) | no estimate extracted | 3 studies · 6652 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Haemoglobin (g/dL) | no estimate extracted | 2 studies · 1365 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Formal tests of cognition | no estimate extracted | 2 studies · 3720 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
School attendance | no estimate extracted | 1 study · 20000 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Death | no estimate extracted | 1 study · 1e+06 participants | Ungraded |
Multiple dose deworming drugs for treating soil‐transmitted intestinal worms in children: effects on nutrition and school performance (outcomes measured more 1 year)
Population: Children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight (kg) | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency |
Height (cm) | no estimate extracted | NR | Very low Downgraded: risk of bias |
Haemoglobin (g/dL) | no estimate extracted | NR | Very low Downgraded: risk of bias |
Formal tests of cognition | no estimate extracted | NR | Very low Downgraded: risk of bias |
School attendance | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency |
Death | no estimate extracted | NR | No studies |