Cochrane · systematic review · CD000230
Zinc supplementation for improving pregnancy and infant outcome
Carducci, B, Keats, EC, Bhutta, ZA · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyZinc supplementation compared to no zinc (with or without placebo) for improving pregnancy and infant outcome
Population: Pregnant women (healthy and probable zinc deficiency)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Preterm birth (< 37 weeks) Zinc supplementation vs no zinc (with or without placebo) | RR 0.87 [0.74, 1.03] | 21 studies · 9851 participants | Low Downgraded: imprecision |
Stillbirth Zinc supplementation vs no zinc (with or without placebo) | RR 1.22 [0.8, 1.88] | 7 studies · 3295 participants | Low Downgraded: imprecision |
Neonatal death Zinc supplementation vs no zinc (with or without placebo) | RR 2.44 [0.4, 14.83] | 3 studies · 1965 participants | Very low Downgraded: imprecision, inconsistency |
Perinatal death Zinc supplementation vs no zinc (with or without placebo) | RR 1.1 [0.81, 1.51] | 2 studies · 2489 participants | Low Downgraded: imprecision |
Birthweight Zinc supplementation vs no zinc (with or without placebo) | no estimate extracted | 22 studies · 7977 participants | Low Downgraded: imprecision |
Small‐for‐gestational age or IUGR Zinc supplementation vs no zinc (with or without placebo) | RR 1.02 [0.92, 1.12] | 9 studies · 5330 participants | Moderate |
Low Birthweight (< 2500 g) Zinc supplementation vs no zinc (with or without placebo) | RR 0.94 [0.79, 1.13] | 17 studies · 7399 participants | Moderate |
Zinc supplementation versus no zinc (with or without placebo) for improving pregnancy and infant outcome
Population: Normal pregnant women with no systemic illness
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Preterm birth Zinc supplementation vs no zinc (with or without placebo) | RR 0.86 [0.76, 0.97] | 16 studies · 7637 participants | Moderate |
Stillbirth or neonatal death Zinc supplementation vs no zinc (with or without placebo) | RR 1.12 [0.86, 1.46] | 8 studies · 5100 participants | Low Downgraded: imprecision |
Birthweight Zinc supplementation vs no zinc (with or without placebo) | no estimate extracted | 17 studies · 6757 participants | Low Downgraded: imprecision |
Small‐for‐gestational age Zinc supplementation vs no zinc (with or without placebo) | RR 1.02 [0.94, 1.11] | 8 studies · 4252 participants | Moderate |
Low birthweight Zinc supplementation vs no zinc (with or without placebo) | RR 0.93 [0.78, 1.12] | 14 studies · 5643 participants | Moderate |