Cochrane · systematic review · CD000023
Antibiotics for treatment of sore throat in children and adults
Spinks, A, Glasziou, PP, Del Mar, CB · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 12.5%Moderate 3 · 37.5%High 4 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAntibiotics compared with control for sore throat
Population: adults and children presenting with sore throat
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sore throat: day 3 Antibiotics vs control | RR 0.7 [0.6, 0.8] | 16 studies · 3730 participants | Moderate Downgraded: inconsistency |
Sore throat: 1 week Antibiotics vs control | RR 0.5 [0.34, 0.75] | 14 studies · 3083 participants | Moderate Downgraded: inconsistency |
Fever: day 3 Antibiotics vs control | RR 0.75 [0.53, 1.07] | 8 studies · 1443 participants | High |
Headache: day 3 Antibiotics vs control | RR 0.49 [0.34, 0.7] | 4 studies · 1020 participants | High |
Rheumatic fever (within 2 months, clinical diagnosis) Antibiotics vs control | Peto OR 0.32 [0.18, 0.58] | 17 studies · 12132 participants | Moderate Downgraded: inconsistency |
Glomerulonephritis (within 1 month, clinical diagnosis) Antibiotics vs control | Peto OR 0.07 [0, 1.32] | 10 studies · 5147 participants | Low Downgraded: imprecision |
Quinsy (within 2 months, clinical diagnosis) Antibiotics vs control | Peto OR 0.16 [0.07, 0.35] | 7 studies · 2367 participants | High |
Otitis media (within 14 days, clinical diagnosis) Antibiotics vs control | Peto OR 0.21 [0.11, 0.4] | 10 studies · 3646 participants | High |
Comparison
Population: patients presenting with sore throat
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sore throat: day 3 | no estimate extracted | 15 studies · 3621 participants | High |
Sore throat: day 7 | no estimate extracted | 13 studies · 2974 participants | High |
Rheumatic fever | no estimate extracted | 16 studies · 10101 participants | High |
Glomerulonephritis | no estimate extracted | 10 studies · 5147 participants | Low |
Quinsy | no estimate extracted | 8 studies · 2433 participants | High |
Otitis media | no estimate extracted | 11 studies · 3760 participants | High |
Comparison
Population: patients presenting with sore throat
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sore throat: day 3 | no estimate extracted | 15 studies · 3621 participants | High |
Sore throat: day 7 | no estimate extracted | 13 studies · 2974 participants | High |
Rheumatic fever | no estimate extracted | 16 studies · 10101 participants | High |
Glomerulonephritis | no estimate extracted | 10 studies · 5147 participants | Low |
Quinsy | no estimate extracted | 8 studies · 2433 participants | High |
Otitis media | no estimate extracted | 11 studies · 3760 participants | High |