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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
448 questions in 37 reviews · Multiple Sclerosis and Rare Diseases of the CNS
current versionsNo studies 50 · 11.2%Ungraded 14 · 3.1%Very low 132 · 29.5%Low 160 · 35.7%Moderate 76 · 17%High 16 · 3.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Intervention (no. of studies/participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Pegylated interferon beta‐1a (Direct evidence; 1 RCT; 1512 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.68 [0.56, 0.82] | 1 study · 1512 participants | Low |
Intervention NR Mitoxantrone (Direct evidence; 1 RCT; 51 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.4 [0.21, 0.74] | 1 study · 51 participants | Low |
Intervention NR Natalizumab (Direct evidence; 1 RCT; 942 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.52 [0.43, 0.63] | 1 study · 942 participants | High |
Intervention NR Teriflunomide (Direct evidence; 1 RCT; 1169 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.66 [0.55, 0.78] | 1 study · 1169 participants | Low |
Intervention NR Placebo · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Intervention (no. of studies/participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Alemtuzumab No direct evidence · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.57 [0.47, 0.68] | NR | High |
Intervention NR Azathioprine (Direct evidence; 1 RCT; 59 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.77 [0.51, 1.18] | 1 study · 59 participants | Very low |
Intervention NR Cladribine (Direct evidence; 1 RCT; 1326 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.53 [0.44, 0.64] | 1 study · 1326 participants | High |
Intervention NR Dimethylfumarate (Direct evidence; 2 RCTs; 2307 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.62 [0.55, 0.7] | 2 studies · 2307 participants | Moderate |
Intervention NR Azathioprine (Direct evidence; 1 RCT; 59 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.91 [0.58, 1.43] | 1 study · 59 participants | Very low |
Intervention NR Fingolimod (Direct evidence; 2 RCTs; 2355 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.54 [0.48, 0.6] | 2 studies · 2355 participants | Moderate |
Intervention NR Glatiramer acetate (Direct evidence; 3 RCsT; 1014 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.84 [0.76, 0.93] | 3 participants | Moderate |
Intervention NR Immunoglobulins (Direct evidence; 2 RCTs; 192 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.73 [0.59, 0.9] | 2 studies · 192 participants | Low |
Intervention NR Interferon beta 1a‐1b No direct evidence · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 1.21 [0.66, 2.19] | 1 participants | Very low |
Intervention NR Interferon beta‐1b (Betaferon) (Direct evidence; 1 RCT; 372 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.85 [0.76, 0.94] | 1 study · 372 participants | Low |
Intervention NR Interferon beta‐1a (Avonex, Rebif) (Direct evidence; 3 RCTs; 1629 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.84 [0.78, 0.91] | 1 study · 3 participants | Moderate |
Intervention NR Laquinimod (Direct evidence; 3 RCTs; 3457 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.83 [0.76, 0.91] | 3 studies · 3457 participants | Low |
Intervention NR Mitoxantrone (Direct evidence; 1 RCT; 51 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.47 [0.27, 0.8] | 1 study · 51 participants | Low |
Intervention NR Natalizumab (Direct evidence; 1 RCT; 942 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.56 [0.48, 0.65] | 1 study · 942 participants | High |
Intervention NR Ponesimod No direct evidence · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.58 [0.48, 0.7] | NR | Moderate |
Intervention NR Daclizumab (Direct evidence; 1 RCT; 621 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.55 [0.42, 0.73] | 1 study · 621 participants | Moderate |
Intervention NR Teriflunomide (Direct evidence; 1 RCT; 1088 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.82 [0.71, 0.94] | 1 study · 1088 participants | Very low |
Intervention NR Placebo · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Intervention (no. of studies/participants) Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Interferon beta‐1b (Betaferon) (Direct evidence; 2 RCTs; 403 participants) Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.86 [0.67, 1.11] | 1 study · 2 participants | Very low |
Intervention NR Placebo Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Intervention (no. of studies and participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Alemtuzumab No direct evidence · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.67 [0.46, 0.99] | NR | Low |
Intervention NR Azathioprine (Direct evidence; 1 RCT; 59 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.6 [0.22, 1.63] | 1 study · 59 participants | Very low |
Intervention NR Cladribine (Direct evidence; 1 RCT; 1326 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.72 [0.56, 0.91] | 1 study · 1326 participants | Low |
Intervention NR Dimethylfumarate (Direct evidence; 2 RCTs; 2307 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.65 [0.55, 0.77] | 2 studies · 2307 participants | Low |
Intervention NR Fingolimod No direct evidence · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.48 [0.39, 0.57] | NR | Moderate |
Intervention NR Fingolimod (Direct evidence; 2 RCTs; 2355 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.68 [0.56, 0.83] | 2 studies · 2355 participants | Low |
Intervention NR Glatiramer acetate (Direct evidence; 3 RCTs; 1014 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.74 [0.61, 0.89] | 3 studies · 1014 participants | Very low |
Intervention NR Immunoglobulins (Direct evidence; 2 RCTs; 190 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.75 [0.41, 1.37] | 2 studies · 190 participants | Very low |
Intervention NR Interferon beta 1a‐1b No direct evidence · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 3.19 [0.31, 33.21] | 1 participants | Very low |
Intervention NR Interferon beta‐1b (Betaferon) (Direct evidence; 1 RCT; 372 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.77 [0.62, 0.94] | 1 study · 372 participants | Low |
Intervention NR Interferon beta‐1a (Avonex, Rebif) (Direct evidence; 2 RCTs; 1069 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.92 [0.73, 1.16] | 1 study · 2 participants | Low |
Intervention NR Laquinimod (Direct evidence; 3 RCTs; 3451 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.78 [0.63, 0.96] | 3 studies · 3451 participants | Very low |
Intervention NR Mitoxantrone (Direct evidence; 1 RCT; 51 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.2 [0.05, 0.83] | 1 study · 51 participants | Very low |
Intervention NR Natalizumab (Direct evidence; 1 RCT; 942 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.59 [0.46, 0.75] | 1 study · 942 participants | Moderate |
Intervention NR Ocrelizumab No direct evidence · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.61 [0.41, 0.9] | NR | Very low |
Intervention NR Glatiramer acetate (Direct evidence; 2 RCTs; 1454 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins,… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.64 [0.55, 0.75] | 2 studies · 1454 participants | Low |
Intervention NR Ofatumumab No direct evidence · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.54 [0.38, 0.77] | NR | Very low |
Intervention NR Ozanimod No direct evidence · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 1.19 [0.74, 1.91] | NR | Very low |
Intervention NR Ponesimod No direct evidence · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.63 [0.41, 0.96] | NR | Very low |
Intervention NR Teriflunomide (Direct evidence; 1 RCT; 1088 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | RR 0.76 [0.61, 0.95] | 1 study · 1088 participants | Very low |
Intervention NR Placebo · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer… Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis (2024) · Cochrane | no estimate extracted | NR | No studies |