Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 32 findings · 2 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 5 · 15.6%GRADE not reported 0 · 0%Very low 5 · 15.6%Low 16 · 50%Moderate 6 · 18.8%High 0 · 0%

Probiotics vs other active intervention

Grade ≥ 3 diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics may leads to lower severity of diarrhoea: grade 3 or higher compared with other active treatment (low certainty).

1 finding from 1 review

Probiotics vs other active intervention

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

It is very uncertain whether probiotics changes requiring rescue medication for diarrhoea compared with other active treatment (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics showed no clear difference in requiring rescue medication for diarrhoea compared with placebo (moderate certainty).

2 findings from 1 review