Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 60%High 2 · 40%

WBRT with radiosensitisers (radiosen) vs WBRT

Brain tumour response rates: complete response (CR) and partial response (PR) combinedNo. of participants: 847(6 RCTs) · patients with newly diagnosed multiple brain metastases

WBRT with radiosensitisers (radiosen) showed no clear difference in brain tumour response rates: complete response (CR) and partial… compared with WBRT alone (high certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
OR 0.84 [0.63, 1.11]
Studies not reported
High

WBRT with radiosensitisers (radiosen) vs WBRT

Adverse effectsNo. of participants: 1754(9 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

WBRT with radiosensitisers (radiosen) vs WBRT

Quality of lifeNo. of participants: 271(2 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

WBRT with radiosensitisers (radiosen) vs WBRT

Symptom controlNo. of participants: 1814(3 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

WBRT with radiosensitisers (radiosen) vs WBRT

Overall survivalNo. of participants: 2631(8 RCTs) · patients with newly diagnosed multiple brain metastases

WBRT with radiosensitisers (radiosen) showed no clear difference in overall survivalNo. of participants: 2631(8 RCTs) compared with WBRT alone (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
HR 1.05 [0.99, 1.12]
Studies not reported
Moderate