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Evidence found and GRADE certainty

27 questions · 28 findings · 4 reviews · Common Mental Disorders · Headline outcomes only

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No studies found 3 · 10.7%GRADE not reported 0 · 0%Very low 2 · 7.1%Low 12 · 42.9%Moderate 9 · 32.1%High 2 · 7.1%

Augmentation of current antidepressant (various) with cariprazine (1 mg/d to 4.5 mg/d) vs augmentation of current antidepressant (various) with placebo

Dropouts ‐ Any dose · treatment‐resistant depression in adults

Augmentation of current antidepressant (various) with cariprazine (1… probably leads to higher dropouts ‐ any dose compared with augmentation of current antidepressant (various) with placebo (moderate certainty).

1 finding from 1 review

Augmentation of current antidepressant (various) with cariprazine (1 mg/d to 4.5 mg/d) vs augmentation of current antidepressant (various) with placebo

> 50% reduction in depressive symptoms · treatment‐resistant depression in adults

Augmentation of current antidepressant (various) with cariprazine (1… probably leads to higher response (≥ 50% improvement in MADRS score) ‐ any dose compared with augmentation of current antidepressant (various) with placebo (moderate certainty).

1 finding from 1 review

Augmentation of current antidepressant (various) with cariprazine (1 mg/d to 4.5 mg/d) vs augmentation of current antidepressant (various) with placebo

Remission · treatment‐resistant depression in adults

Augmentation of current antidepressant (various) with cariprazine (1… showed no clear difference in remission (MADRS total score ≤ 10) ‐ any dose compared with augmentation of current antidepressant (various) with placebo (moderate certainty).

1 finding from 1 review

Augmentation of current antidepressant (various) with quetiapine (150 mg/d to 300 mg/d) vs augmentation of current antidepressant (various) with placebo

Dropouts ‐ Any dose · treatment‐resistant depression in adults

Augmentation of current antidepressant (various) with quetiapine… showed no clear difference in dropouts ‐ Any dose compared with augmentation of current antidepressant (various) with placebo (moderate certainty).

1 finding from 1 review

Augmentation of current antidepressant (various) with quetiapine (150 mg/d to 300 mg/d) vs augmentation of current antidepressant (various) with placebo

Response (≥ 50% reduction in MADRS or HAM‐D score) ‐ Any dose · treatment‐resistant depression in adults

Augmentation of current antidepressant (various) with quetiapine… probably leads to higher response (≥ 50% reduction in MADRS or HAM‐D score) ‐ Any dose compared with augmentation of current antidepressant (various) with placebo (moderate certainty).

1 finding from 1 review

Augmentation of current antidepressant (various) with quetiapine (150 mg/d to 300 mg/d) vs augmentation of current antidepressant (various) with placebo

Remission · treatment‐resistant depression in adults

Augmentation of current antidepressant (various) with quetiapine… probably leads to higher remission (MADRS score ≤ 8/HAM‐D score ≤ 7) ‐ Any dose compared with augmentation of current antidepressant (various) with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Prevalence of psychological trauma (short term: up to 3 months postpartum) Measured by various scales ‐ Impact of Event Scale (IES), MINI‐PTSD · Women of any age who had given birth within one month of the intervention being offered

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Prevalence of depression or depressive symptoms (short term: up to 3 months postpartum) Measured by various scales ‐ EPDS, HADS · Women of any age who had given birth within one month of the intervention being offered

The review found no eligible studies for this question.

1 finding from 1 review

Any early psychological intervention vs inactive control (usual care care, attention control, waitlist)

Diagnosis of PTSD after treatment · various

It is very uncertain whether any early psychological intervention changes PTSD diagnosis: post‐treatment compared with waiting list/usual care (very low certainty).

1 finding from 1 review