Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 1 reviews · Skin · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 45.5%Low 0 · 0%Moderate 6 · 54.5%High 0 · 0%

Valaciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in incidence of HSL during use of the preventative intervention (by… compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Incidence of HSL during use of the preventative intervention (by culture) · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in incidence of HSL during use of the preventative intervention (by… compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (suppressive regimen vs episodic regimen)

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

It is very uncertain whether valaciclovir (suppressive regimen changes adverse effects during use of the preventative intervention compared with episodic regimen) (very low certainty).

1 finding from 1 review