Findings

What do systematic reviews say?

3 questions · 4 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 100%High 0 · 0%

Cases of typhoid fever, Year 1 · adults and children aged 5 years of age and older

Ty21a vaccine (three doses) probably leads to lower cases of typhoid fever, Year 1 compared with control (moderate certainty).

2 findings from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 0.55 [0.35, 0.86]
3 studies · 76296 participants
Moderate
Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 0.41 [0.29, 0.57]
3 studies · 76296 participants
Moderate

Cases of typhoid fever, Year 3 · adults and children aged 5 years of age and older

Ty21a vaccine (three doses) probably leads to lower cases of typhoid fever, Year 3 compared with control (moderate certainty).

1 finding from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 0.44 [0.25, 0.76]
3 studies · 76296 participants
Moderate

Cumulative cases of typhoid fever at 2.5 to 3 years · adults and children aged 5 years of age and older

Ty21a vaccine (three doses) probably leads to lower cumulative cases of typhoid fever at 2.5 to 3 years compared with control (moderate certainty).

1 finding from 1 review

Vaccines for preventing typhoid fever 2018 · Cochrane Headline outcomes only
RR 0.5 [0.39, 0.65]
4 studies · 235239 participants
Moderate