Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Skin

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 1 · 25%High 0 · 0%

Twice daily or more vs once daily topical corticosteroid

Clinician‐reported signs of eczema: IGA (number with cleared or marked improvement); short term (earliest time point within 1‐4 weeks) · children and adults, most with moderate to severe eczema

Twice daily or more showed no clear difference in clinician‐reported signs of eczema: IGA (number with cleared or… compared with once daily topical corticosteroid (moderate certainty).

1 finding from 1 review

Strategies for using topical corticosteroids in children and adults with eczema 2022 · Cochrane Headline outcomes only
OR 0.97 [0.68, 1.38]
15 studies · 1970 participants
Moderate

Twice daily or more vs once daily topical corticosteroid

Patient‐reported symptoms of eczema · children and adults, most with moderate to severe eczema

Twice daily or more showed no clear difference in patient‐reported symptoms of eczema: PGA (number with cleared or… compared with once daily topical corticosteroid (low certainty).

1 finding from 1 review

Strategies for using topical corticosteroids in children and adults with eczema 2022 · Cochrane Headline outcomes only
OR 1.91 [0.62, 5.83]
2 studies · 300 participants
Low

Twice daily or more vs once daily topical corticosteroid

Local adverse events: skin thinning; end of treatment (2‐5 weeks) · children and adults, most with moderate to severe eczema

1 finding from 1 review

Strategies for using topical corticosteroids in children and adults with eczema 2022 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1423 participants
Low

Twice daily or more vs once daily topical corticosteroid

Systemic adverse events: abnormal cortisol; end of treatment (1‐6 weeks) · children and adults, most with moderate to severe eczema

1 finding from 1 review

Strategies for using topical corticosteroids in children and adults with eczema 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 249 participants
Very low