Findings

What do systematic reviews say?

19 questions · 19 findings · 3 reviews · Headline outcomes only

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No studies found 3 · 15.8%GRADE not reported 2 · 10.5%Very low 0 · 0%Low 3 · 15.8%Moderate 11 · 57.9%High 0 · 0%

Trazodone vs placebo

Number of nocturnal awakenings · sleep disturbances in dementia

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Trazodone vs placebo

Number of participants reporting an adverse event · sleep disturbances in dementia

Trazodone showed no clear difference in reporting ≥ 1 adverse event compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
RR 0.67 [0.23, 1.89]
1 study · 30 participants
Low

Trazodone vs placebo

Cognitive function · sleep disturbances in dementia

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Moderate

Trazodone vs placebo

Quality of life · sleep disturbances in dementia

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Trazodone vs placebo

Carer burden, well‐being or quality of life · sleep disturbances in dementia

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Trazodone vs placebo

Total nocturnal sleep time (minutes) · sleep disturbances in dementia

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Trazodone vs placebo

Consolidated nocturnal sleep time · sleep disturbances in dementia

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacotherapies for sleep disturbances in dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paroxetine vs trazodone

Failure to respond at endpoint (6‐12 weeks) · patients with depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with trazodone (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.71 [0.21, 2.41]
1 study · 108 participants
Moderate

Paroxetine vs trazodone

Failure to respond at 1‐4 weeks · patients with depression

Paroxetine showed no clear difference in failure to respond at 1‐4 weeks compared with trazodone (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.54 [0.25, 1.19]
1 study · 108 participants
Moderate

Paroxetine vs trazodone

Failure to respond at 16‐24 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs trazodone

Failure to remit at endpoint · patients with depression

Paroxetine showed no clear difference in failure to remit at endpoint compared with trazodone (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.06 [0.47, 2.38]
1 study · 108 participants
Moderate

Paroxetine vs trazodone

SMD at endpoint · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Moderate

Paroxetine vs trazodone

Failure to complete ‐ any cause ‐ · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs trazodone

Participants with at least some Side Effects · patients with depression

Paroxetine showed no clear difference in participants with at least some Side Effects compared with trazodone (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.68 [0.3, 1.55]
1 study · 108 participants
Moderate

Fluoxetine vs trazodone

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine showed no clear difference in failure to respond (reduction ≥ 50% on HDRS) compared with trazodone (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.49 [0.13, 1.86]
3 studies · 110 participants
Moderate

Fluoxetine vs trazodone

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 203 participants
Moderate

Fluoxetine vs trazodone

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with trazodone (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.51 [0.23, 1.13]
4 studies · 230 participants
Moderate

Fluoxetine vs trazodone

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with trazodone (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.23 [0.04, 1.51]
2 studies · 70 participants
Moderate

Fluoxetine vs trazodone

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with trazodone (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.66 [0.2, 2.19]
3 studies · 110 participants
Moderate