Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 4 · 57.1%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Transfusions continued vs transfusions halted

Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and normalised TCD velocities

Transfusions continued may leads to lower proportion of participants developing new or progressive SCI lesions compared with transfusions halted (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.29 [0.09, 0.97]
1 study · 77 participants
Low

Transfusions continued vs transfusions halted

All‐cause mortality · prevention of SCI in people with SCD and normalised TCD velocities

It is very uncertain whether transfusions continued changes all‐cause mortality compared with transfusions halted (very low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
Peto OR 8 [0.16, 404.12]
1 study · 79 participants
Very low

Transfusions continued vs transfusions halted

Stroke · prevention of SCI in people with SCD and normalised TCD velocities

It is very uncertain whether transfusions continued changes clinical stroke compared with transfusions halted (very low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.22 [0.01, 4.35]
1 study · 79 participants
Very low

Transfusions continued vs transfusions halted

SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD and normalised TCD velocities

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 79 participants
Very low

Transfusions continued vs transfusions halted

SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and normalised TCD velocities

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 79 participants
Very low

Transfusions continued vs transfusions halted

Cognitive function ‐ not reported · prevention of SCI in people with SCD and normalised TCD velocities

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Transfusions continued vs transfusions halted

Quality of life ‐ not reported · prevention of SCI in people with SCD and normalised TCD velocities

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found