What do systematic reviews say?

Topical bleomycin vs placebo or no treatment

It is very uncertain whether topical bleomycin changes oral cancer development compared with placebo or no treatment (very low certainty).

• Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes

  up to 7 years
  RR 3.00 [0.32, 27.83]
  1 study · 20 participants
  Very low

Topical bleomycin vs placebo or no treatment

It is very uncertain whether topical bleomycin changes clinical resolution (oral lesion not completely resolved) compared with placebo or no treatment (very low certainty).

• Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes

  3 months
  RR 0.55 [0.29, 1.04]
  1 study · 22 participants
  Very low

Topical bleomycin vs placebo or no treatment

• Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes

  up to 3 months
  SoF 5, Safety of the intervention up to 3 months: 'All patients in the bleomycin group developed erythema with erosion by the end of the applications, whereas erythema developed in the placebo group. Discomfort was…
  1 study
  GRADE not reported

Topical bleomycin vs placebo or no treatment

It is very uncertain whether topical bleomycin changes improvement of histological features (not improved) compared with placebo or no treatment (very low certainty).

• Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes

  3 months
  RR 0.49 [0.22, 1.10]
  1 study · 21 participants
  Very low