Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

46 questions · 46 findings · 2 reviews · Skin

No studies found 0 · 0%GRADE not reported 11 · 23.9%Very low 17 · 37%Low 15 · 32.6%Moderate 3 · 6.5%High 0 · 0%

Ketoconazole vs placebo

Failure to achieve complete resolution Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole may leads to lower failure to achieve complete resolution Clinical assessment compared with placebo (low certainty).

1 finding from 1 review

Ciclopirox vs placebo

Side effects (combined for face and scalp) Self report · patients with seborrhoeic dermatitis

Ciclopirox showed no clear difference in side effects (combined for face and scalp) Self reported compared with placebo (moderate certainty).

1 finding from 1 review

Ketoconazole vs placebo

Side effects Self report · patients with seborrhoeic dermatitis

It is very uncertain whether ketoconazole changes side effects Self report compared with placebo (very low certainty).

1 finding from 1 review

Ketoconazole vs steroids

Failure to achieve complete resolution (combined for face and scalp) Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution (combined for face and scalp)… compared with steroids (low certainty).

1 finding from 1 review

Ketoconazole vs steroids

Side effects (combined for face and scalp) Self report · patients with seborrhoeic dermatitis

Ketoconazole probably leads to lower side effects (combined for face and scalp) Self report compared with steroids (moderate certainty).

1 finding from 1 review

Ketoconazole vs ciclopirox

Failure to achieve complete resolution ‐ Face only Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution ‐ Face only Clinical assessment compared with ciclopirox (low certainty).

1 finding from 1 review

Ketoconazole vs ciclopirox

Failure to achieve complete resolution (long term) ‐ Face only Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution (long term) ‐ Face only… compared with ciclopirox (low certainty).

1 finding from 1 review

Ketoconazole vs ciclopirox

Side effects ‐ Scalp only Self reported · patients with seborrhoeic dermatitis

It is very uncertain whether ketoconazole changes side effects ‐ Scalp only Self reported compared with ciclopirox (very low certainty).

1 finding from 1 review

Ciclopirox vs placebo

Failure to achieve complete resolution (combined for face and scalp) Clinical assessment · patients with seborrhoeic dermatitis

Ciclopirox probably leads to lower failure to achieve complete resolution (combined for face and scalp)… compared with placebo (moderate certainty).

1 finding from 1 review

Naftifine 1% cream once or twice daily vs placebo cream once or twice daily

Recurrence · patients with tinea cruris and tinea corporis

Naftifine 1% cream once or twice daily showed no clear difference in relapse or recurrence Evidence of clinical or mycological infection… compared with placebo cream once or twice daily (low certainty).

1 finding from 1 review

Azoles vs allylamines

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes adverse effects Reported by investigators 'and' or 'or' participants compared with allylamines (very low certainty).

1 finding from 1 review

Azoles vs allylamines

Relapse or recurrence Evidence of clinical and mycological relapse after the end of treatment. Assessed in 3 studies · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes relapse or recurrence Evidence of clinical and mycological relapse… compared with allylamines (very low certainty).

1 finding from 1 review