Health‐related quality of life (HRQL) · chronic rhinosinusitis
Topical antifungal may leads to lower heath‐related quality of life (HRQL) compared with placebo/no treatment (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Disease severity score · chronic rhinosinusitis
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Generic HRQL (change from baseline) · chronic rhinosinusitis
2 findings from 1 review
no estimate extracted
Studies not reported
Low
no estimate extracted
Studies not reported
Low
Adverse effects ‐ epistaxis · chronic rhinosinusitis
Topical antifungal showed no clear difference in adverse effects ‐ epistaxis compared with placebo/no treatment (low certainty).
1 finding from 1 review
RR 0.97 [0.14, 6.63]
Studies not reported
Low
Adverse effects: headache · chronic rhinosinusitis
It is very uncertain whether topical antifungal changes adverse effects ‐ headache compared with placebo/no treatment (very low certainty).
1 finding from 1 review
RR 1.26 [0.6, 2.63]
Studies not reported
Very low
Other adverse effects: local irritation · chronic rhinosinusitis
Topical antifungal showed no clear difference in adverse effects ‐ local irritation compared with placebo/no treatment (low certainty).
1 finding from 1 review
RR 2.29 [0.61, 8.62]
Studies not reported
Low
Adverse effects ‐ hepatic toxicity · chronic rhinosinusitis
Systemic antifungal showed no clear difference in adverse effects ‐ hepatic toxicity compared with placebo/no treatment (low certainty).
1 finding from 1 review
RR 3.35 [0.14, 78.6]
Studies not reported
Low
Gastrointestinal adverse events · chronic rhinosinusitis
Systemic antifungal showed no clear difference in adverse effects ‐ gastrointestinal disturbances compared with placebo/no treatment (low certainty).
1 finding from 1 review
RR 0.37 [0.04, 3.36]
Studies not reported
Low
Allergic adverse events · chronic rhinosinusitis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Generic quality of life measures · chronic rhinosinusitis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life (HRQL) · chronic rhinosinusitis
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Disease severity score · chronic rhinosinusitis
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Failure to achieve complete resolution Clinical assessment · patients with seborrhoeic dermatitis
Ketoconazole may leads to lower failure to achieve complete resolution Clinical assessment compared with placebo (low certainty).
1 finding from 1 review
Side effects (combined for face and scalp) Self report · patients with seborrhoeic dermatitis
Ciclopirox showed no clear difference in side effects (combined for face and scalp) Self reported compared with placebo (moderate certainty).
1 finding from 1 review
Side effects Self report · patients with seborrhoeic dermatitis
It is very uncertain whether ketoconazole changes side effects Self report compared with placebo (very low certainty).
1 finding from 1 review
Failure to achieve complete resolution (combined for face and scalp) Clinical assessment · patients with seborrhoeic dermatitis
Ketoconazole showed no clear difference in failure to achieve complete resolution (combined for face and scalp)… compared with steroids (low certainty).
1 finding from 1 review
Failure to achieve complete resolution (long term, combined for face and scalp) Clinical assessment · patients with seborrhoeic dermatitis
1 finding from 1 review
Side effects (combined for face and scalp) Self report · patients with seborrhoeic dermatitis
Ketoconazole probably leads to lower side effects (combined for face and scalp) Self report compared with steroids (moderate certainty).
1 finding from 1 review
Failure to achieve complete resolution ‐ Face only Clinical assessment · patients with seborrhoeic dermatitis
Ketoconazole showed no clear difference in failure to achieve complete resolution ‐ Face only Clinical assessment compared with ciclopirox (low certainty).
1 finding from 1 review
Failure to achieve complete resolution (long term) ‐ Face only Clinical assessment · patients with seborrhoeic dermatitis
Ketoconazole showed no clear difference in failure to achieve complete resolution (long term) ‐ Face only… compared with ciclopirox (low certainty).
1 finding from 1 review