Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

16 questions · 16 findings · 1 reviews

No studies found 6 · 37.5%GRADE not reported 0 · 0%Very low 2 · 12.5%Low 3 · 18.8%Moderate 4 · 25%High 1 · 6.3%

Three doses HPV vaccine vs control

Penile or anal intraepithelial neoplasia at up to 3‐year · 10‐ to 26‐year‐old males

Three doses HPV vaccine showed no clear difference in penile or anal intraepithelial neoplasia at up to 3‐year compared with control (low certainty).

1 finding from 1 review

Three doses HPV vaccine vs control

External genital lesions (any genotype) at up to 3‐year · 10‐ to 26‐year‐old males

Three doses HPV vaccine probably leads to lower external genital lesions (any genotype) at up to 3‐year compared with control (moderate certainty).

1 finding from 1 review

Three doses HPV vaccine vs control

Overall systemic events and general symptoms · 10‐ to 26‐year‐old males

Three doses HPV vaccine showed no clear difference in overall systemic events and general symptoms at 15‐day compared with control (moderate certainty).

1 finding from 1 review

Two doses of HPV vaccine vs three doses of HPV vaccine

Antibody response (immunogenicity) · 9‐ to 15‐year‐old females

Two doses of HPV vaccine probably leads to lower antibody response (immunogenicity) compared with three doses of HPV vaccine (moderate certainty).

1 finding from 1 review

Two doses of HPV vaccine vs three doses of HPV vaccine

Serious adverse events at up to 5‐year · 9‐ to 15‐year‐old females

It is very uncertain whether two doses of HPV vaccine changes serious adverse events at up to 5‐year compared with three doses of HPV vaccine (very low certainty).

1 finding from 1 review