Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Oral medicine and oral cancer · All outcomes

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 100%High 0 · 0%

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Adverse events associated with treatment · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to higher adverse events associated with treatment compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
RR 1.31 [1.11, 1.54]
2 studies · 746 participants
Moderate

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower recurrence compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
RR 0.58 [0.48, 0.70]
3 studies · 633 participants
Moderate

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Locoregional recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower locoregional recurrence compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 0.58 [0.43, 0.78]
4 studies · 458 participants
Moderate

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Mortality (overall survival) · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower mortality (overall survival) compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 0.64 [0.50, 0.83]
4 studies · 883 participants
Moderate

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower disease-free survival (new disease, progression, and mortality) compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 0.56 [0.45, 0.70]
5 studies · 954 participants
Moderate