Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

10 questions · 10 findings · 2 reviews · Musculoskeletal

No studies found 5 · 50%GRADE not reported 0 · 0%Very low 3 · 30%Low 2 · 20%Moderate 0 · 0%High 0 · 0%

Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone

Sustained clinically inactive diseasec · children and young people with JIA

Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in sustained clinically inactive diseaseb(12 months) compared with intra‐articular glucocorticoid alone (low certainty).

1 finding from 1 review

Intervention not reported

Change in pain Visual Analog Scale (VAS) at 12 weeks (0 to 10 scale; lower score means less pain) · people with rheumatoid arthritis

It is very uncertain whether the intervention changes change in pain Visual Analog Scale (VAS) at 12 weeks (0 to 10 scale;… (very low certainty).

1 finding from 1 review

Intervention not reported

Change in measure of disease activity Disease Activity Score (DAS‐28‐ESR) at 12 weeks (0 to 10 score; lower score means less disease activity) · people with rheumatoid arthritis

It is very uncertain whether the intervention changes change in measure of disease activity Disease Activity Score… (very low certainty).

1 finding from 1 review

Intervention not reported

Change in function Health Assessment Questionnaire (HAQ) at 12 weeks (0 to 3 score; lower score means better function) · people with rheumatoid arthritis

It is very uncertain whether the intervention changes change in function Health Assessment Questionnaire (HAQ) at 12 weeks… (very low certainty).

1 finding from 1 review

Intervention not reported

Radiographic progression · people with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Short‐term serious adverse events · people with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Long‐term adverse effects or toxicity · people with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Withdrawals – overall (at 8 to 12 weeks) · people with rheumatoid arthritis

The intervention may leads to lower withdrawals – overall (at 8 to 12 weeks) (low certainty).

1 finding from 1 review