Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 2 reviews

No studies found 7 · 46.7%GRADE not reported 0 · 0%Very low 6 · 40%Low 2 · 13.3%Moderate 0 · 0%High 0 · 0%

Summary of findings table ‐ Methylprednisolone vs dexamethasone

Clinical improvement: discharged alive ‐ not reported · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Methylprednisolone vs dexamethasone

Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Methylprednisolone vs dexamethasone

Hospital‐acquired infections ‐ not reported · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Methylprednisolone vs dexamethasone

All‐cause mortality up to 30 days · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19

It is very uncertain whether summary of findings table ‐ Methylprednisolone changes all‐cause mortality up to 30 days compared with dexamethasone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

CAS improvement (decrease) by 2 or more points · thyroid‐associated ophthalmopathy

Summary of findings table ‐ Rituximab showed no clear difference in CAS improvement (decrease) by 2 or more points compared with intravenous methylprednisolone (low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

NOSPECS improvement (decrease) by 2 classes or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes NOSPECS improvement (decrease) by 2 or more classes compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Proptosis improvement (decrease) by 2 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes proptosis improvement (decrease) by 2 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Palpebral aperture improvement (decrease) by 3 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes palpebral aperture improvement (decrease) by 3 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Motility improvement (increase) by 1 class or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes motility improvement (increase) by 1 class or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review