Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Proportion of infants with repeat seizure before hospital discharge · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Maintenance ASM changes proportion of infants with repeat seizure before hospital discharge compared with no maintenance ASM after achieving seizure control (very low certainty).

1 finding from 1 review

Anti‐seizure medications for neonates with seizures 2023 · Cochrane Headline outcomes only
RR 0.76 [0.56, 1.01]
2 studies · 373 participants
Very low

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Mortality or neurodevelopmental disability at 18 to 24 months' corrected age ‐ not reported · neonates with clinically diagnosed seizures

The review found no eligible studies for this question.

1 finding from 1 review

Anti‐seizure medications for neonates with seizures 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Mortality before hospital discharge · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in mortality before hospital discharge compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Anti‐seizure medications for neonates with seizures 2023 · Cochrane Headline outcomes only
RR 0.69 [0.39, 1.22]
2 studies · 373 participants
Low

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Mortality at 18‐24 months · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in mortality at 18‐24 months compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Anti‐seizure medications for neonates with seizures 2023 · Cochrane Headline outcomes only
RR 0.94 [0.34, 2.61]
1 study · 111 participants
Low

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Neurodevelopmental disability at 18 to 24 months among survivors · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in neurodevelopmental disability at 18‐24 months compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Anti‐seizure medications for neonates with seizures 2023 · Cochrane Headline outcomes only
RR 0.89 [0.13, 6.12]
1 study · 108 participants
Low

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Proportion of infants who develop epilepsy post‐discharge · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in proportion of infants who develop epilepsy post‐discharge compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Anti‐seizure medications for neonates with seizures 2023 · Cochrane Headline outcomes only
RR 3.18 [0.69, 14.72]
1 study · 126 participants
Low