Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).
1 finding from 1 review
Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in incidence of respiratory depression compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).
1 finding from 1 review
Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in additional drugs required to stop the seizure compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).
1 finding from 1 review
Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures
1 finding from 1 review
Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intranasal lorazepam (moderate certainty).
1 finding from 1 review
Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
1 finding from 1 review
Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Seizure freedom · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure cessation compared with intravenous lorazepam (moderate certainty).
1 finding from 1 review
Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
1 finding from 1 review
Additional drugs required to stop the seizure: additional dose of the trial drug required · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous midazolam showed no clear difference in additional drugs required to terminate the seizure: additional dose… compared with intravenous lorazepam (moderate certainty).
1 finding from 1 review
Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure recurrence within 24 hours compared with intravenous lorazepam (moderate certainty).
1 finding from 1 review
Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Additional drugs required to stop the seizure: intravenous lorazepam required · Children with acute tonic‐clonic seizures
Summary of findings ‐ Buccal midazolam may leads to lower additional drugs required to stop the seizure: intravenous lorazepam… compared with rectal diazepam (low certainty).
1 finding from 1 review