What do systematic reviews say?

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Summary of findings ‐ Intranasal lorazepam may leads to lower additional drugs required to terminate the seizure: 2 or more… compared with intramuscular paraldehyde (low certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.38 [0.18, 0.81]
  1 study · 160 participants
  Low

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Summary of findings ‐ Intranasal lorazepam showed no clear difference in seizure recurrence within 24 hours compared with intramuscular paraldehyde (low certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.73 [0.31, 1.71]
  1 study · 160 participants
  Low

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Summary of findings ‐ Intranasal lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intramuscular paraldehyde (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 1.22 [0.99, 1.52]
  1 study · 160 participants
  Moderate

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 160 participants
  Low

Summary of findings ‐ Intravenous lorazepam vs intranasal lorazepam

Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intranasal lorazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 1.07 [0.77, 1.49]
  1 study · 58 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intranasal lorazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 58 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intranasal lorazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 141 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intranasal lorazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Intravenous lorazepam vs intranasal lorazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Intravenous lorazepam vs intranasal lorazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found