What do systematic reviews say?

Summary of findings: BT vs external beam radiotherapy (EBRT)

The review found no eligible studies for this question.

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: BT vs external beam radiotherapy (EBRT)

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Summary of findings: BT vs external beam radiotherapy (EBRT)

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 348 participants
  GRADE not reported

Summary of findings: BT vs external beam radiotherapy (EBRT)

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 348 participants
  GRADE not reported

Summary of findings: IMRT vs 3DCRT

Summary of findings: IMRT showed no clear difference in mean GI symptom scores (EORTC‐QLQPR25 scale; lower scores better) compared with 3DCRT (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 181 participants
  Low

Summary of findings: IMRT vs 3DCRT

Summary of findings: IMRT may leads to lower acute and late GI toxicity Grade 2+ compared with 3DCRT (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.48 [0.26, 0.88]
  4 studies · 444 participants
  Low

Summary of findings: IMRT vs 3DCRT

Summary of findings: IMRT may leads to lower diarrhoea (grade 2+) compared with 3DCRT (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.38 [0.22, 0.68]
  1 study · 72 participants
  Low

Summary of findings: IMRT vs 3DCRT

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT showed no clear difference in death from all causes compared with no EBRT (moderate certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  HR 0.99 [0.82, 1.2]
  2628 participants
  Moderate

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT showed no clear difference in endometrial carcinoma‐related death compared with no EBRT (moderate certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  HR 0.96 [0.72, 1.28]
  2965 participants
  Moderate

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT leads to lower locoregional recurrence compared with no EBRT (high certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  HR 0.36 [0.25, 0.52]
  2965 participants
  High

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT leads to higher severe acute toxicity compared with no EBRT (high certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  RR 4.68 [1.35, 16.16]
  1328 participants
  High

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT leads to higher severe late toxicity compared with no EBRT (high certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  RR 2.58 [1.61, 4.11]
  3501 participants
  High

Selenium vs no intervention

The review found no eligible studies for this question.

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Selenium vs no intervention

The review found no eligible studies for this question.

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Selenium vs no intervention

Summary of findings: Selenium may leads to lower diarrhoea (grade 2+) compared with no intervention (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.4
  1 study · 81 participants
  Low

Selenium vs no intervention

The review found no eligible studies for this question.

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Glutamine vs placebo

The review found no eligible studies for this question.

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Glutamine vs placebo

Summary of findings: Glutamine showed no clear difference in acute and late GI toxicity (grade 2+) compared with placebo (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 2.4 [0.68, 8.53]
  1 study · 69 participants
  Low

Glutamine vs placebo

Summary of findings: Glutamine showed no clear difference in diarrhoea (grade 2+) compared with placebo (high certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.98 [0.78, 1.24]
  4 studies · 289 participants
  High