Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Duration of treatment effect · glabellar lines
1 finding from 1 review
- no estimate extracted1 study · 100 participantsModerate
Findings
What do systematic reviews say?
10 questions · 10 findings · 1 reviews
No studies found 1 · 10%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 10%Moderate 5 · 50%High 3 · 30%
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U
Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in participant assessment success by analysing scores and scales ‐ 4… compared with onabotulinumtoxinA 20U (high certainty).
1 finding from 1 review
- RR 1 [0.92, 1.08]1 study · 388 participantsHigh
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U
Major adverse events (eyelid ptosis, eyelid sensory disorder, strabismus) · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in major adverse events ‐ Any major adverse events (eyelid ptosis,… compared with onabotulinumtoxinA 20U (moderate certainty).
1 finding from 1 review
- OR 2.65 [0.77, 9.09]1 study · 433 participantsModerate
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U
Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in physician assessment of success by analysing scores and scales ‐ 4… compared with onabotulinumtoxinA 20U (high certainty).
1 finding from 1 review
- RR 1.01 [0.95, 1.06]1 study · 388 participantsHigh
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U
Total adverse events · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in total adverse events compared with onabotulinumtoxinA 20U (moderate certainty).
1 finding from 1 review
- RR 1.02 [0.67, 1.54]2 studies · 492 participantsModerate
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U
Duration of treatment effect ‐ not measured · glabellar lines
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Participant assessment of success by analysing scores and scales ‐ 20 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U leads to higher participant assessment of success by analysing scores and scales ‐… compared with placebo (high certainty).
1 finding from 1 review
- RR 5.33 [1.67, 16.99]1 study · 300 participantsHigh
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Major adverse events (eyelid ptosis, eyelid sensory disorder, strabismus) · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in major adverse events (eyelid ptosis, eyelid sensory disorder,… compared with placebo (moderate certainty).
1 finding from 1 review
- RR 3.36 [0.88, 12.87]7 studies · 1294 participantsModerate
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Physician assessment of success · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U probably leads to higher physician assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).
1 finding from 1 review
- RR 15.78 [8.75, 28.45]7 studies · 1060 participantsModerate
Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo
Total adverse events · glabellar lines
Summary of Findings Table ‐ AbobotulinumtoxinA 50U may leads to higher total adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 1.25 [1.05, 1.49]8 studies · 1471 participantsLow