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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Airways

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 1 · 14.3%High 1 · 14.3%

Sublingual immunotherapy vs control

Exacerbation requiring ED or hospital visit Weighted mean duration of studies: 31 weeks · people with asthma

It is very uncertain whether sublingual immunotherapy changes exacerbation requiring ED or hospital visit Weighted mean duration… compared with control (very low certainty).

1 finding from 1 review

Sublingual immunotherapy vs control

Serious adverse events Weighted mean duration of studies: 49 weeks · people with asthma

Sublingual immunotherapy showed no clear difference in serious adverse events Weighted mean duration of studies: 56 weeks compared with control (moderate certainty).

1 finding from 1 review

Sublingual immunotherapy vs control

Exacerbation requiring OCS Weighted mean duration of studies: 25 weeks · people with asthma

It is very uncertain whether sublingual immunotherapy changes exacerbation requiring OCS Weighted mean duration of studies: 58 weeks compared with control (very low certainty).

1 finding from 1 review

Sublingual immunotherapy vs control

All adverse events Weighted mean duration of studies: 60 weeks** · people with asthma

Sublingual immunotherapy leads to higher all adverse events Weighted mean duration of studies: 62 weeks** compared with control (high certainty).

1 finding from 1 review