Overall survival · children and adults with Smith‐Lemli‐Opitz syndrome
The review found no eligible studies for this question.
1 finding from 1 review
Change in neurobehavioral manifestations · children and adults with Smith‐Lemli‐Opitz syndrome
1 finding from 1 review
Statin‐related adverse events · children and adults with Smith‐Lemli‐Opitz syndrome
It is very uncertain whether statins with cholesterol supplementation changes statin‐related adverse events compared with cholesterol supplementation only (very low certainty).
1 finding from 1 review
Growth · children and adults with Smith‐Lemli‐Opitz syndrome
1 finding from 1 review
Changes in biochemical markers plasma dehydrocholesterol levels (mM); plasma cholesterol levels (mM); plasma 7DHC levels (mM); plasma CoQ levels (uM); CSF cholesterol levels (ug/mL); CSF dehydrocholesterol levels (ug/mL) · children and adults with Smith‐Lemli‐Opitz syndrome
1 finding from 1 review
QoL · children and adults with Smith‐Lemli‐Opitz syndrome
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Change in carotid intima‐media thickness (mm) ‐ at 2 years · children with familial hypercholesterolemia
1 finding from 1 review
Intervention not reported
Change in serum LDL cholesterol level (%) ‐ at end of · children with familial hypercholesterolemia
1 finding from 1 review
Intervention not reported
Change in measures of growth and maturation: change in puberty proportion with Tanner stage ≧ 1 level ‐ at 2 years · children with familial hypercholesterolemia
The intervention showed no clear difference in change in measures of growth and maturation: change in puberty… (low certainty).
1 finding from 1 review
Intervention not reported
Liver dysfunction: proportion with changed aspartate aminotransferase or alanine aminotransferase levels (> 3x ULN) ‐ at all time points · children with familial hypercholesterolemia
1 finding from 1 review
Intervention not reported
Myopathy: proportion with changed serum creatine kinase levels (>10x ULN) ‐ at all time points · children with familial hypercholesterolemia
1 finding from 1 review
Intervention not reported
Change in endothelial function: Change in flow‐mediated dilatation of brachial artery (%) · children with familial hypercholesterolemia
1 finding from 1 review
Intervention not reported
Adverse events ‐ at one year · children with familial hypercholesterolemia
The intervention showed no clear difference in adverse events ‐ at one year (moderate certainty).
1 finding from 1 review