Findings

What do systematic reviews say?

13 questions · 15 findings · 2 reviews · Airways

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No studies found 0 · 0%GRADE not reported 2 · 13.3%Very low 5 · 33.3%Low 5 · 33.3%Moderate 3 · 20%High 0 · 0%

Adults: higher dose/longer course vs lower dose/shorter course

Re‐admission during · Adults with acute asthma

Adults: higher dose/longer course showed no clear difference in re‐admission in compared with lower dose/shorter course (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.35 [0.38, 4.79]
4 studies · 142 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

Asthma severity and symptoms · Adults with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

Asthma symptoms Complete resolution by day 28 · Adults with acute asthma

Adults: higher dose/longer course showed no clear difference in asthma symptoms Complete resolution by day 28 compared with lower dose/shorter course (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.55 [0.13, 2.26]
1 study · 35 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

Exacerbations · Adults with acute asthma

It is very uncertain whether adults: higher dose/longer course changes new exacerbation in compared with lower dose/shorter course (very low certainty).

2 findings from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.98 [0.17, 5.56]
2 studies · 55 participants
Very low
Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.62 [0.23, 1.68]
3 studies · 122 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

FEV1 % predicted · Adults with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 41 participants
Very low

Adults: higher dose/longer course vs lower dose/shorter course

All adverse events · Adults with acute asthma

It is very uncertain whether adults: higher dose/longer course changes all adverse events compared with lower dose/shorter course (very low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 4.15 [0.94, 18.41]
1 study · 43 participants
Very low

Children: higher dose/longer course vs lower dose/shorter course

Re‐admission during · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 98 participants
Very low

Children: higher dose/longer course vs lower dose/shorter course

Asthma symptoms · children with acute asthma

Children: higher dose/longer course showed no clear difference in asthma symptoms Symptom free by 7 days compared with lower dose/shorter course (moderate certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.22 [0.67, 2.19]
1 study · 201 participants
Moderate

Children: higher dose/longer course vs lower dose/shorter course

Serious adverse events · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 201 participants
GRADE not reported

Children: higher dose/longer course vs lower dose/shorter course

Exacerbations · children with acute asthma

Children: higher dose/longer course showed no clear difference in new exacerbation during compared with lower dose/shorter course (low certainty).

2 findings from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.38 [0.25, 7.47]
2 studies · 231 participants
Low
Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 2.17 [0.67, 7.01]
1 study · 100 participants
Very low

Children: higher dose/longer course vs lower dose/shorter course

FEV1 % predicted · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
GRADE not reported

Children: higher dose/longer course vs lower dose/shorter course

All adverse events · children with acute asthma

Children: higher dose/longer course showed no clear difference in all adverse events compared with lower dose/shorter course (moderate certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.67 [0.11, 4.08]
1 study · 201 participants
Moderate

Formoterol vs short‐acting beta2‐agonist

Exacerbations requiring oral corticosteroids ‐ adults · people with asthma

Formoterol probably leads to lower patients with an exacerbation requiring a course of oral… compared with short‐acting beta2‐agonist (moderate certainty).

1 finding from 1 review

Formoterol versus short‐acting beta‐agonists as relief medication for adults and children with asthma 2010 · Cochrane Headline outcomes only
OR 0.84 [0.77, 0.91]
6 studies · 21591 participants
Moderate