Lithium vs carbamazepine
Adverse effects: 1. Sedation · acute mania
Lithium showed no clear difference in adverse event: sedation compared with carbamazepine (low certainty).
1 finding from 1 review
- OR 0.16 [0.01, 3.64]1 study · 27 participantsLow
Findings
What do systematic reviews say?
8 questions · 8 findings · 2 reviews · Common Mental Disorders
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 37.5%Low 2 · 25%Moderate 1 · 12.5%High 2 · 25%
Lithium vs ARIPIPRAZOLE
Adverse events: somnolence/sedation · acute mania
Lithium showed no clear difference in adverse events: somnolence/sedation compared with aripiprazole (moderate certainty).
1 finding from 1 review
- OR 0.56 [0.26, 1.23]1 study · 313 participantsModerate
Valproate vs lithium
Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania
Valproate showed no clear difference in individual adverse events ‐ Sedation At 3 weeks (secondary… compared with lithium (low certainty).
1 finding from 1 review
- OR 0.96 [0.35, 2.67]1 study · 105 participantsLow
Valproate vs lithium
Adverse events: somnolence/sedation · Children and adolescents with acute mania
It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 8 weeks (secondary… compared with lithium (very low certainty).
1 finding from 1 review
- OR 1.59 [0.84, 3]1 study · 190 participantsVery low
Valproate vs OLANZAPINE
Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania
Valproate leads to lower adverse events ‐ Sedation At 3‐12 weeks (secondary tolerability… compared with olanzapine (high certainty).
1 finding from 1 review
- OR 0.5 [0.28, 0.91]2 studies · 536 participantsHigh
Valproate vs RISPERIDONE
Adverse effects: 1. Sedation · Children and adolescents with acute mania
It is very uncertain whether valproate changes adverse events ‐ Sedation At 8 weeks (secondary tolerability outcome) compared with risperidone (very low certainty).
1 finding from 1 review
- OR 0.5 [0.28, 0.91]1 study · 189 participantsVery low
Valproate vs placebo
Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania
Valproate showed no clear difference in individual adverse events ‐ Sedation At 3‐8 weeks (secondary… compared with placebo (high certainty).
1 finding from 1 review
- OR 1.76 [0.95, 3.24]5 studies · 932 participantsHigh
Valproate vs placebo
Adverse effects: 1. Sedation · Children and adolescents with acute mania
It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 4 weeks (secondary… compared with placebo (very low certainty).
1 finding from 1 review
- OR 0.4 [0.12, 1.37]1 study · 150 participantsVery low