S‐adenosyl methionine as adjunctive treatment vs placebo
Change in depressive symptoms · depression in adults
1 finding from 1 review
- no estimate extracted1 study · 73 participantsLow
Findings
What do systematic reviews say?
5 questions · 5 findings · 1 reviews
No studies found 1 · 20%GRADE not reported 0 · 0%Very low 1 · 20%Low 3 · 60%Moderate 0 · 0%High 0 · 0%
S‐adenosyl methionine as adjunctive treatment vs placebo
Secondary outcome: acceptability of treatment · depression in adults
It is very uncertain whether S‐adenosyl methionine as adjunctive treatment changes acceptability Participants dropping out of treatment during the… compared with placebo (very low certainty).
1 finding from 1 review
- RR 0.7 [0.31, 1.56]1 study · 73 participantsVery low
S‐adenosyl methionine as adjunctive treatment vs placebo
Proportions of participants responding to treatment ≥ 50% reduction in depression score from baseline to end of treatment. A larger RR indicates greater response to treatment in the SAMe group · depression in adults
S‐adenosyl methionine as adjunctive treatment may leads to higher proportions of participants responding to treatment ≥ 50% reduction… compared with placebo (low certainty).
1 finding from 1 review
- RR 2.62 [1.17, 5.83]1 study · 73 participantsLow
S‐adenosyl methionine as adjunctive treatment vs placebo
Depression remission · depression in adults
S‐adenosyl methionine as adjunctive treatment may leads to higher proportions of participants achieving remission depression rating… compared with placebo (low certainty).
1 finding from 1 review
- RR 3.05 [1.11, 8.39]1 study · 73 participantsLow
S‐adenosyl methionine as adjunctive treatment vs placebo
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found