Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

81 questions · 81 findings · 6 reviews · Infectious Diseases

No studies found 14 · 17.3%GRADE not reported 7 · 8.6%Very low 31 · 38.3%Low 17 · 21%Moderate 8 · 9.9%High 4 · 4.9%

Fluoroquinolones vs beta‐lactams

Other adverse events clinical criteria · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes other adverse events clinical criteria compared with beta‐lactams (very low certainty).

1 finding from 1 review

Fluoroquinolones vs macrolides

Other adverse events clinical criteria · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes other adverse events clinical criteria compared with macrolides (very low certainty).

1 finding from 1 review

Fluoroquinolones vs beta‐lactams

Relapse · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes relapse ‐ All trials clinical criteria compared with beta‐lactams (very low certainty).

1 finding from 1 review

Fluoroquinolones vs beta‐lactams

Serious adverse events clinical criteria · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes serious adverse events clinical criteria compared with beta‐lactams (very low certainty).

1 finding from 1 review

Fluoroquinolones vs beta‐lactams

Discontinuation of medication due to adverse events · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes adverse events leading to discontinuation of treatment compared with beta‐lactams (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Death from any cause · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in death from any cause compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

TB‐related death · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in TB‐related death compared with standard regimen (low certainty).

1 finding from 1 review