What do systematic reviews say?

Pulse cyclophosphamide vs continuous cyclophosphamide

Pulse cyclophosphamide showed no clear difference in dialysis at end of study compared with continuous cyclophosphamide (low certainty).

• Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
  RR 1.9 [0.92, 3.91]
  4 studies · 245 participants
  Low

Pulse cyclophosphamide vs continuous cyclophosphamide

Pulse cyclophosphamide showed no clear difference in remission at 6 months compared with continuous cyclophosphamide (low certainty).

• Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
  RR 1.03 [0.93, 1.13]
  2 studies · 176 participants
  Low

Pulse cyclophosphamide vs continuous cyclophosphamide

Pulse cyclophosphamide may leads to higher relapse at the end of compared with continuous cyclophosphamide (low certainty).

• Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
  RR 1.79 [1.11, 2.87]
  4 studies · 235 participants
  Low

Pulse cyclophosphamide vs continuous cyclophosphamide

Pulse cyclophosphamide showed no clear difference in adverse events ‐ treatment failure compared with continuous cyclophosphamide (low certainty).

• Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
  RR 1.36 [0.115, 12.56]
  2 studies · 82 participants
  Low

Pulse cyclophosphamide vs continuous cyclophosphamide

Pulse cyclophosphamide showed no clear difference in serious infections compared with continuous cyclophosphamide (low certainty).

• Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
  RR 0.71 [0.38, 1.33]
  4 studies · 278 participants
  Low

Pulse cyclophosphamide vs continuous cyclophosphamide

Pulse cyclophosphamide showed no clear difference in death at final compared with continuous cyclophosphamide (low certainty).

• Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
  RR 0.77 [0.44, 1.32]
  4 studies · 278 participants
  Low

Pulse cyclophosphamide vs continuous cyclophosphamide

• Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 52 participants
  Low