Findings

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4 questions · 4 findings · 1 reviews

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No studies found 2 · 50%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 0 · 0%High 0 · 0%

Prophylactic perindopril (2 mg to 4 mg daily) vs placebo

Change in cardiac function: number of patients with EF < 45% · boys with DMD, normal cardiac examination and LVEF > 55% at baseline

It is very uncertain whether prophylactic perindopril (2 mg to 4 mg daily) changes change in cardiac function: number of patients with EF < 45% compared with placebo (very low certainty).

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
RR 1.04 [0.07, 15.77]
1 study · 57 participants
Very low

Prophylactic perindopril (2 mg to 4 mg daily) vs placebo

Size of metabolically abnormal areas of myocardium · boys with DMD, normal cardiac examination and LVEF > 55% at baseline

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prophylactic perindopril (2 mg to 4 mg daily) vs placebo

Improvements in quality of life measures · boys with DMD, normal cardiac examination and LVEF > 55% at baseline

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prophylactic perindopril (2 mg to 4 mg daily) vs placebo

Adverse events · boys with DMD, normal cardiac examination and LVEF > 55% at baseline

Prophylactic perindopril (2 mg to 4 mg daily) showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
RR 1.16 [0.78, 1.72]
1 study · 57 participants
Low