Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Epilepsy

No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%

Withdrawals due to any reason · women with seizures due to catamenial epilepsy

Progesterone showed no clear difference in number of withdrawals from the study: for any reason compared with placebo (moderate certainty).

1 finding from 1 review

Treatments for seizures in catamenial (menstrual‐related) epilepsy 2021 · Cochrane Headline outcomes only
RR 1.56 [0.81, 3]
2 studies · 168 participants
Moderate

Adverse events: any adverse event · women with seizures due to catamenial epilepsy

Progesterone showed no clear difference in adverse events: any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Treatments for seizures in catamenial (menstrual‐related) epilepsy 2021 · Cochrane Headline outcomes only
RR 0.85 [0.59, 1.24]
1 study · 130 participants
Moderate

Quality of life · women with seizures due to catamenial epilepsy

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for seizures in catamenial (menstrual‐related) epilepsy 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Seizure freedom · women with seizures due to catamenial epilepsy

Progesterone showed no clear difference in seizure freedom: all seizures compared with placebo (low certainty).

1 finding from 1 review

Treatments for seizures in catamenial (menstrual‐related) epilepsy 2021 · Cochrane Headline outcomes only
RR 4.03 [0.21, 76.21]
1 study · 130 participants
Low

50% or greater reduction in seizure frequency · women with seizures due to catamenial epilepsy

Progesterone showed no clear difference in responder rate: 50% or greater reduction in all seizures compared with placebo (moderate certainty).

1 finding from 1 review

Treatments for seizures in catamenial (menstrual‐related) epilepsy 2021 · Cochrane Headline outcomes only
RR 1.14 [0.56, 2.32]
1 study · 130 participants
Moderate

Seizure frequency · women with seizures due to catamenial epilepsy

1 finding from 1 review

Treatments for seizures in catamenial (menstrual‐related) epilepsy 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 166 participants
Low