Findings

What do systematic reviews say?

14 questions · 14 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 1 · 7.1%GRADE not reported 4 · 28.6%Very low 8 · 57.1%Low 1 · 7.1%Moderate 0 · 0%High 0 · 0%

Preoperative blood transfusion vs no transfusion

Transfusion related complications ‐ any · people with SCD

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 434 participants
GRADE not reported

Preoperative blood transfusion vs no transfusion

Serious complications related to SCD ‐ painful crises · people with SCD

It is very uncertain whether preoperative blood transfusion changes serious complications related to SCD ‐ painful crises compared with no transfusion (very low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
OR 1.91 [0.61, 6.04]
2 studies · 434 participants
Very low

Preoperative blood transfusion vs no transfusion

Serious infection · people with SCD

It is very uncertain whether preoperative blood transfusion changes serious infection compared with no transfusion (very low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
OR 1.29 [0.29, 5.71]
2 studies · 434 participants
Very low

Preoperative blood transfusion vs no transfusion

Perioperative complications ‐ any surgery‐related · people with SCD

Preoperative blood transfusion showed no clear difference in perioperative complications ‐ any surgery‐related compared with no transfusion (low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.24 [0.03, 2.05]
1 study · 65 participants
Low

Preoperative blood transfusion vs no transfusion

Quality of life · people with SCD

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
GRADE not reported

Preoperative blood transfusion vs no transfusion

All‐cause mortality · people with SCD

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 434 participants
GRADE not reported

Preoperative blood transfusion vs no transfusion

Serious complications related to SCD ‐ ACS · people with SCD

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 434 participants
Very low

Aggressive vs conservative blood transfusion

Transfusion‐related complications ‐ cholecystectomy complications (any) · people with SCD

It is very uncertain whether aggressive changes transfusion‐related complications ‐ cholecystectomy complications… compared with conservative blood transfusion (very low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1.85 [0.89, 3.88]
1 study · 230 participants
Very low

Aggressive vs conservative blood transfusion

All‐cause mortality · people with SCD

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 230 participants
GRADE not reported

Aggressive vs conservative blood transfusion

Serious complications related to SCD ‐ cholecystectomy ACS · people with SCD

It is very uncertain whether aggressive changes serious complications related to SCD ‐ cholecystectomy ACS compared with conservative blood transfusion (very low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.84 [0.38, 1.84]
1 study · 230 participants
Very low

Aggressive vs conservative blood transfusion

Serious complications related to SCD ‐ cholecystectomy painful crisis · people with SCD

It is very uncertain whether aggressive changes serious complications related to SCD ‐ cholecystectomy painful crisis compared with conservative blood transfusion (very low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.3 [0.09, 1.04]
1 study · 230 participants
Very low

Aggressive vs conservative blood transfusion

Serious infection ‐ cholecystectomy · people with SCD

It is very uncertain whether aggressive changes serious infection ‐ cholecystectomy compared with conservative blood transfusion (very low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1.75 [0.59, 5.18]
1 study · 230 participants
Very low

Aggressive vs conservative blood transfusion

Perioperative complications ‐ cholecystectomy complications (any) · people with SCD

It is very uncertain whether aggressive changes perioperative complications ‐ cholecystectomy complications (any) compared with conservative blood transfusion (very low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.75 [0.36, 1.55]
1 study · 230 participants
Very low

Aggressive vs conservative blood transfusion

Quality of life · people with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found