Findings

What do systematic reviews say?

17 questions · 17 findings · 1 reviews

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No studies found 8 · 47.1%GRADE not reported 0 · 0%Very low 6 · 35.3%Low 3 · 17.6%Moderate 0 · 0%High 0 · 0%

Phenobarbital and opioid vs opioid

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Treatment failure To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Phenobarbital and opioid vs opioid

Seizures To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Phenobarbital and opioid vs opioid

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Phenobarbital and opioid vs opioid

Days' pharmacological treatment · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Adverse events To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Clonidine and opioid vs phenobarbital and opioid

Treatment failure To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes treatment failure To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 2.27 [0.98, 5.25]
2 studies · 93 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Seizures To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes seizures To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 3 [0.13, 71.15]
1 study · 68 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Mortality before hospital discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Clonidine and opioid vs phenobarbital and opioid

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 91 participants
Low

Clonidine and opioid vs phenobarbital and opioid

Days' pharmacological treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 91 participants
Low

Clonidine and opioid vs phenobarbital and opioid

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 1.55 [0.44, 5.4]
2 studies · 93 participants
Very low

Phenobarbital vs diazepam

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital vs chlorpromazine

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital vs supportive care

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found