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Evidence found and GRADE certainty

4 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Periodontal disease (present) vs Individuals without periodontal disease (by LOA)

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Periodontal disease was associated with higher odds of poor OHRQoL (OR 1.15, 95% CI 1.12-1.18; 3 studies; no heterogeneity; ungraded).

1 finding from 1 review

Genome-wide common variants (additive dosage; present-study GWAS) vs Genome-wide significance threshold (P<5E-8)

Periodontal disease - genome-wide-significant loci (present study) · Japanese adults (present-study cohort)

The present Japanese GWAS found no genome-wide-significant loci for periodontal disease (top suggestive rs12624579/SYNDIG1); ungraded.

1 finding from 1 review
  • Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomes
    Lifelong (germline genotype) · Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort) · Present-study GWAS (Japanese)
    In the present Japanese GWAS, no loci reached genome-wide significance for periodontal disease; several loci reached the suggestive level (P<1E-5). Top-associated variant rs12624579 (SYNDIG1 intron).
    1 study · 45525 participants
    GRADE not reported

Genome-wide common variants (additive dosage; GWAS meta-analysis) vs Genome-wide significance threshold (P<5E-8)

Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease cases vs controls

The meta-analysis found no novel loci for periodontal disease; the European SIGLEC5/chr19 locus did not replicate in Japanese populations; ungraded.

1 finding from 1 review
  • Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomes
    Lifelong (germline genotype) · Population-based genetic association study (Japanese + European cohorts) · Meta-analysis: present study + GLIDE + UKB + BBJ
    Meta-analysis of periodontal disease identified only previously known loci; no novel loci. The chromosome-19 SIGLEC5 locus associated with periodontitis in Europeans was not replicated in Japanese populations (present…
    4 studies · 764572 participants
    GRADE not reported

Genome-wide common variants (aggregate additive; LD score regression) vs Not applicable (variance-component estimate)

Periodontal disease - SNP-based heritability · Japanese adults (present-study cohort)

SNP-based heritability of periodontal disease was low (h2=0.0519, SE 0.0182); ungraded.

1 finding from 1 review