Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 5 reviews · Headline outcomes only

No studies found 2 · 16.7%GRADE not reported 0 · 0%Very low 5 · 41.7%Low 3 · 25%Moderate 2 · 16.7%High 0 · 0%

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Cure · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

The review found no eligible studies for this question.

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Adverse events · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

Partial oral treatment showed no clear difference in adverse events compared with conventional intravenous treatment of endocarditis on the left side… (low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Congestive heart failure · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes congestive heart failure compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Need for cardiac surgical interventions · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes need for cardiac surgicalinterventions compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Septic embolism · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes septic embolism compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Uncontrolled infection · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

The review found no eligible studies for this question.

1 finding from 1 review

Mycophenolate sodium + oral steroids vs oral steroids alone

Complete or partial remission · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in complete or partial remission Time frame: 24 weeks to end of treatment compared with oral steroids alone (moderate certainty).

1 finding from 1 review

Oral alkylating agents ± steroids vs steroids or placebo or both, or no treatment

Total remission (complete or partial) at final · primary membranous nephropathy in adults with nephrotic syndrome

Oral alkylating agents ± steroids probably leads to higher total remission (complete or partial) at final compared with placebo/no treatment/steroids (moderate certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Composite outcome: symptoms of leg cramps (intensity and frequency) Partial improvement: decrease in intensity and frequency · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes composite outcome: symptoms of leg cramps (intensity and frequency)… compared with placebo/no treatment (very low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Treatment response at 6 months: partial remission · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 6 months: partial remission compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Complete or partial remission · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 6 months: complete or partial remission compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review