Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Epilepsy

No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 1 · 16.7%High 0 · 0%

Seizure freedom · patients with drug‐resistant epilepsy

PUFA may leads to higher seizure freedom compared with placebo (low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation for drug‐resistant epilepsy 2016 · Cochrane Headline outcomes only
RR 20 [2.84, 140.99]
1 study · 70 participants
Low

50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐ Older (19 years or more) · patients with drug‐resistant epilepsy

PUFA showed no clear difference in 50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐… compared with placebo (low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation for drug‐resistant epilepsy 2016 · Cochrane Headline outcomes only
RR 0.57 [0.19, 1.75]
2 studies · 78 participants
Low

50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐ Younger (< 19 years) · patients with drug‐resistant epilepsy

PUFA may leads to higher 50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐… compared with placebo (low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation for drug‐resistant epilepsy 2016 · Cochrane Headline outcomes only
RR 33 [4.77, 228.15]
1 study · 70 participants
Low

50% or greater reduction in seizure frequency · patients with drug‐resistant epilepsy

PUFA showed no clear difference in 50% reduction in seizures frequency (6 weeks) compared with placebo (moderate certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation for drug‐resistant epilepsy 2016 · Cochrane Headline outcomes only
RR 4.67 [0.58, 37.52]
1 study · 58 participants
Moderate

Potential adverse effects ‐ not reported · patients with drug‐resistant epilepsy

The review found no eligible studies for this question.

1 finding from 1 review

Polyunsaturated fatty acid supplementation for drug‐resistant epilepsy 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gastrointestinal effects · patients with drug‐resistant epilepsy

PUFA showed no clear difference in gastrointestinal effects compared with placebo (low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation for drug‐resistant epilepsy 2016 · Cochrane Headline outcomes only
RR 0.78 [0.32, 1.89]
2 studies · 85 participants
Low