Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 100%Moderate 0 · 0%High 0 · 0%

Prophylaxis with standard therapeutic factor concentrate vs pegylated liposome FVIII formulation

Annualized joint Bleeding Rate (AjBR) · children or adults with hemophilia A

Prophylaxis with standard therapeutic factor concentrate showed no clear difference in AJBR compared with pegylated liposome FVIII formulation (low certainty).

1 finding from 1 review

Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously treated… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 143 participants
Low

Prophylaxis with standard therapeutic factor concentrate vs pegylated liposome FVIII formulation

ABR · children or adults with hemophilia A

Prophylaxis with standard therapeutic factor concentrate showed no clear difference in ABR compared with pegylated liposome FVIII formulation (low certainty).

1 finding from 1 review

Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously treated… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 143 participants
Low

Prophylaxis with standard therapeutic factor concentrate vs pegylated liposome FVIII formulation

Any reported adverse effects · children or adults with hemophilia A

1 finding from 1 review

Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously treated… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 143 participants
Low