28‐Day all‐cause mortality (adult and paediatric patients) · patients with severe sepsis or septic shock
Human recombinant activated protein C showed no clear difference in 28‐Day all‐cause mortality (adult and paediatric patients) compared with placebo (moderate certainty).
1 finding from 1 review
In‐hospital mortality (adult and paediatric patients) · patients with severe sepsis or septic shock
Human recombinant activated protein C showed no clear difference in in‐hospital mortality (adult and paediatric patients) compared with placebo (moderate certainty).
1 finding from 1 review
Serious bleeding events in adult and paediatric patients (days 0 to 28) · patients with severe sepsis or septic shock
Human recombinant activated protein C probably leads to higher serious bleeding events in adult and paediatric patients (days 0 to… compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events (adult and paediatric patients) · patients with severe sepsis or septic shock
Human recombinant activated protein C showed no clear difference in serious adverse events (adult and paediatric patients) compared with placebo (moderate certainty).
1 finding from 1 review
Mortality in paediatric population (subgroup) · critically ill participants with ALI and ARDS
INO showed no clear difference in mortality in paediatric population (subgroup) compared with control group (moderate certainty).
1 finding from 1 review
RR 0.78 [0.51, 1.18]
185 participants
Moderate
Intervention not reported
Successful cannulation at the first attempt · paediatric patients
The intervention probably leads to higher successful cannulation at the first attempt (moderate certainty).
1 finding from 1 review
Intervention not reported
Rate of complications (haematoma or ischaemia) · paediatric patients
The intervention probably leads to lower rate of complications (haematoma or ischaemia) (moderate certainty).
1 finding from 1 review
Intervention not reported
Successful cannulation within the first 2 attempts · paediatric patients
The intervention probably leads to higher successful cannulation within the first 2 attempts (moderate certainty).
1 finding from 1 review