What do systematic reviews say?

Cyclamen europaeum vs placebo

The review found no eligible studies for this question.

• Cyclamen europaeum extract for acute sinusitis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cyclamen europaeum vs placebo

Cyclamen europaeum probably leads to higher proportion of participants with any adverse event compared with placebo (moderate certainty).

• Cyclamen europaeum extract for acute sinusitis 2018 · Cochrane Headline outcomes only
  RR 2.11 [1.35, 3.29]
  2 studies · 147 participants
  Moderate

Slow passive expiration vs control

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 71 participants
  Low

Slow passive expiration vs control

Slow passive expiration showed no clear difference in change in the severity status of bronchiolitis Assessed using a… compared with control (low certainty).

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 434 participants
  Low

Slow passive expiration vs control

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 565 participants
  Very low

Forced expiration vs control

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 628 participants
  High

Forced expiration vs control

It is very uncertain whether forced expiration changes change in the severity status of bronchiolitis Assessed using a… compared with control (very low certainty).

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 132 participants
  Very low

Forced expiration vs control

Forced expiration leads to higher adverse events ( compared with control (high certainty).

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  RR 1
  2 studies · 599 participants
  High

Maintenance fluids vs restricted fluids

Maintenance fluids showed no clear difference in death ‐ all participants compared with restricted fluids (low certainty).

• Fluid therapy for acute bacterial meningitis 2016 · Cochrane Headline outcomes only
  RR 0.82 [0.53, 1.27]
  2 studies · 407 participants
  Low

Maintenance fluids vs restricted fluids

Maintenance fluids showed no clear difference in severe neurological sequelae ‐ acute (within the first 4 weeks) compared with restricted fluids (low certainty).

• Fluid therapy for acute bacterial meningitis 2016 · Cochrane Headline outcomes only
  RR 0.67 [0.41, 1.08]
  2 studies · 407 participants
  Low

Maintenance fluids vs restricted fluids

It is very uncertain whether maintenance fluids changes severe neurological sequelae ‐ chronic (after the first 4 weeks) compared with restricted fluids (very low certainty).

• Fluid therapy for acute bacterial meningitis 2016 · Cochrane Headline outcomes only
  RR 0.42 [0.2, 0.89]
  1 study · 351 participants
  Very low